포도상구균 장독소의 비점적이 알레르기비염 마우스에서 알레르기 염증반응에 미치는 영향

김용민; 김응협; 박찬희; 윤여훈; 김진만; 나기상

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자료유형: 학술저널

저자정보: 김용민 김응협 박찬희 윤여훈 김진만 나기상

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제11호

발행연도: 2009.1

수록면: 885 - 892 (8page)

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Background and Objectives The role of Staphylococcus aureus enterotoxin B (SEB) in allergic rhinitis remains controversial. We used a mouse model of airway allergy to determine the effects of nasal instillation of SEB on allergic inflammation. Materials and Method BALB/c mice were intranasally sensitized with compound of Aspergillus melleus proteinase (AMp) and ovalbumin (ova) in the presence (group 3) or absence of SEB (group 2). Control mice were intranasally sensitized with either phosphate buffered saline (PBS)(group 1) or SEB (group 4) alone. The production of serum antigen-specific antibodies and total IgE, and concentrations of cytokines including interleukin-4 (IL-4), IL-5, interferon-γ (IFN-γ) in nasal lavage fluid (NLF) and broncoalveolar lavage fluid (BALF) were compared among the groups. Pathologic studies for eosinophilic infiltrations in the nasal mucosa and peribronchial area were also conducted. Results Serum ova-specific immunoglobulin E (IgE) & immunoglobulin G1 (IgG1) were significantly increased in group 2 and 3 compared to group 1. The concentrations of IL-4 in BALF were significantly increased in group 2, 3, and 4 compared to group 1. The concentrations of IL-5 in BALF and NLF were significantly increased in Group 2, 3, and 4 compared to group 1. The concentrations of IFN-γ were significantly increased in group 3 and 4 compared to group 2 although there was no significant difference among the groups in NLF. Group 2 demonstrates increased infiltration of eosinophils in the nasal mucosa and peribronchial area compared to group 3 and 4. Conclusion These results suggest that the nasal exposure to SEB did not aggravate inflammation in allergic mice.

#Allergic rhinitis·Staphylococcus·Enterotoxin·Eosinophil

참고문헌 (20)

참고문헌 신청

Bachert C / 2002 / Staphylococcus aureus superantigens and airway disease / Curr Allergy Asthma Rep 2 (3) : 252 ~ 258

Bachert C / 2003 / IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma / J Allergy Clin Immunol 111 (5) : 1131 ~ 1132

Bachert C / 2003 / Superantigens and nasal polyps / Curr Allergy Asthma Rep 3 (3) : 523 ~ 531

Bernal A / 1999 / Superantigens in human disease / J Clin Immunol 19 (3) : 149 ~ 157

Fooladi AA / 2008 / In vivo induction of necrosis in mice fibrosarcoma via intravenous injection of type B staphylococcal enterotoxin / Biotechnol Lett 30 (12) : 2053 ~ 2059

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