포도구균장독소에 의한 기도상피세포에서의 Rhinovirus 복제 증가

장용주; 왕종환; 권현자; 정유삼; 이봉재

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자료유형: 학술저널

저자정보: 장용주 왕종환 권현자 정유삼 이봉재

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제11호

발행연도: 2006.1

수록면: 1,071 - 1,076 (6page)

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Background and Objectives：The toxins generated from Staphylococcus aureus, Staphylococcal enterotoxin A (SEA) and B(SEB), are reported to have an important role in the pathogenesis of chronic rhinosinusitis. As a basic step for elucidating the pathophysiologicresponses of the nasal mucosa of chronic rhinosinusitis associated with rhinovirus infection, this study investigated theeffect of SEA and SEB on rhinovirus infection in A549 cells. Materials and Method：The effect of SEA and SEB on the rhinovirus-induced changes in intercellular adhesion molecule-1 (ICAM-1) expression was assessed by flow cytometry. The effect ofstaphylococcal toxins on the rhinovirus-induced cytokine secretion was measured by ELISA. The effect of the replication of rhinovirusin the cells was examined by viral culture with subsequent determination of viral titer. Results：ICAM-1 expression wasincreased in the rhinovirus infection group. Cytokine secretion was also increased in the rhinovirus infection group. But there wasno additional increase due to staphylococcal toxins regarding the ICAM-1 expression and cytokine secretions. Staphylococcal toxinsincreased viral titer in proportion to toxin concentrations. Conclusion：SEA and SEB increased rhinoviral replication in airwayepithelial cells. This result shows that airway epithelial cells with chronic rhinosinusitis are more favorable environments for rhinovirusinfection. (Korean J Otolaryngol 2006;49:1071-6)

#리노바이러스·포도구균장독소·황색포도구균·만성 부비동염. #Rhinovirus·Staphylococcal enterotoxin·Staphylococcus aureus·Chronic sinusitis.

참고문헌 (23)

참고문헌 신청

/ / Colonno RJ. Domains 1and 2 of ICAM-1 are sufficient to bind human rhinovirus. Virus Res1992 : 173 ~ 86

/ / Superantigens interact with MHC class II molecules outside of the antigengroove : 1115 ~ 21

/ / et al. Influence of interleukin-8 challenge in the nasal mucosa in atopicand nonatopic subjects. Am J Respir Crit Care Med 1994 : 1108 ~ 13

/ 1995 / Respiratory syncytialvirus increases IL-8 gene expression and protein release in A549 cells. 269 : 865 ~ 872

/ 1997 / Detection of rhinovirusin sinus brushings of patients with acute community-acquiredsinusitis by reverse transcription-PCR. 35 (7) : 1791 ~ 1793

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