비용을 동반한 만성 비부비동염에서 황색포도상구균 외독소의 역할

박영규; 서성태; 김응협; 김동현; 최진웅; 김용민; 나기상

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자료유형: 학술저널

저자정보: 박영규 서성태 김응협 김동현 최진웅 김용민 나기상

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제53권 제4호

발행연도: 2010.1

수록면: 221 - 227 (7page)

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Background and ObjectivesZZStaphylococcal exotoxins (SEs) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyp (CRSwNP). In the current study, we determined the prevalence of specific immunoglobulin E (IgE) antibodies to SEs in serum and polyp tissues of patients with CRSwNP and tried to find out whether there is an association between the presence of SEs-IgE antibody and eosinophilic inflammation. Subjects and MethodZZBlood, nasal polyp and mucosa samples were obtained from 43 patients undergoing endoscopic sinus surgery for CRSwNP and 11 controls undergoing septoplasty without CRS. Specimens were analyzed for the presence of specific IgE antibody to four SEs [staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC), toxic shock syndrome toxin 1 (TSST-1)] using ImmunoCAP assay. Eosinophil cationic protein (ECP) in serum and nasal polyp tissue were also analyzed using ImmunoCAP. Eosinophil counts were estimated in polyp tissue. ResultsZZSEs-specific IgE antibodies were detected in 13 (30.2%) patients of the CRSwNP group. In contrast, only one (9.1%) control patient had IgE to SEs. Serum ECP level was increased significantly in the CRSwNP group compared with controls. However, there were no significant differences in Lund-MacKay score, the ECP level in the serum and polyp tissue, and eosinophil count in the polyp tissue between the SEs-IgE antibody positive [SEs-IgE Ab (+)]group and the SEs-IgE antibody negative [SEs-IgE Ab (-)] group. ConclusionZZSEs may play a certain role in the pathogenesis of CRSwNP. However, there is no close correlation between the presence of SEs-IgE antibody and eosinophilic inflammation. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:221-7

#Staphylococcal exotoxin·Nasal polyp·Chronic rhinosinusitis.

참고문헌 (23)

참고문헌 신청

Bachert C / 2001 / Total and specific IgE in nasal polyps is related to local eosinophilic inflammation / J Allergy Clin Immunol 107 (4) : 607 ~ 614

Bachert C / 2002 / Staphylococcus aureus enterotoxins: a key in airway disease? / Allergy 57 (6) : 480 ~ 487

Bernal A / 1999 / Superantigens in human disease / J Clin Immunol 19 (3) : 149 ~ 157

Chan J / 2001 / The microbiology of chronic rhinosinusitis: results of a community surveillance study / Ear Nose Throat J 80 (3) : 143 ~ 145

Cohen M / 2009 / Biofilms in chronic rhinosinusitis: a review / Am J Rhinol Allergy 23 (3) : 255 ~ 260

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