지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 373 - 380 (8page)
이용수
초록· 키워드
오류제보하기
We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific IgE and IgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-α (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Moreno-Ancillo A / 1997 / Allergic reactions to Anisakis simplex parasitizing seafood / Ann Allergy Asthma Immunol 79 : 246 ~ 250
2. [학술지(정기간행물)] - Nieuwenhuizen N / 2006 / Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis / J Allergy Clin Immunol 117 : 1098 ~ 1105
3. [학술지(정기간행물)] - Armentia A / 1998 / Occupational asthma by Anisakis simplex / J Allergy Clin Immunol 102 : 831 ~ 834
4. [학술지(정기간행물)] - Barbuzza O / 2009 / Pro tein contact dermatitis and allergic asthma caused by Anisakis simplex / Contact Dermatitis 60 : 239 ~ 240
5. [학술지(정기간행물)] - Jeebhay MF / 2001 / Occupational seafood allergy: A review / Occup Environ Med 58 : 553 ~ 562
2. [학술지(정기간행물)] - Nieuwenhuizen N / 2006 / Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis / J Allergy Clin Immunol 117 : 1098 ~ 1105
3. [학술지(정기간행물)] - Armentia A / 1998 / Occupational asthma by Anisakis simplex / J Allergy Clin Immunol 102 : 831 ~ 834
4. [학술지(정기간행물)] - Barbuzza O / 2009 / Pro tein contact dermatitis and allergic asthma caused by Anisakis simplex / Contact Dermatitis 60 : 239 ~ 240
5. [학술지(정기간행물)] - Jeebhay MF / 2001 / Occupational seafood allergy: A review / Occup Environ Med 58 : 553 ~ 562
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UCI(KEPA) : I410-ECN-0101-2014-510-002511151