Aspergillus 알레르기 비염 마우스 모델에서의 비만세포의 역할

조진희; 이동호; 박찬순; 신지현; 강준명; 이흥엽; 방충일

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자료유형: 학술저널

저자정보: 조진희 이동호 박찬순 신지현 강준명 이흥엽 방충일

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제9호

발행연도: 2006.1

수록면: 912 - 917 (6page)

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Background and Objectives：Mast cells are the main effector cells in the immediate phase of the allergic responses. To evaluatethe role of mast cells on the development of allergen-induced eosinophilic inflammation in a murine model of allergic rhinitis(AR), we compared the responses of mast cell deficient (W/Wv) mice with congenial normal (W/W+) mice. Materials and Method：Mice were sensitized intranasally with an extract of Aspergillus fumigatue (Af) for 3 weeks, and challenged intranasallywith a single dose (acute model) or single dose every day for 5 consecutive days (chronic model). Interleukin (IL)-5 in nasallavage fluids (NLF), histologic examination and Af-specific immunoglobulins (Ig) were examined in W/Wv mice and W/W+mice. Results：In the sensitized W/Wv mice, the number of eosinophils in the nasal mucosa and IL-5 in NLF after repeatedallergen challenge were not significantly different from those of W/W+ mice. In contrast, the number of eosinophils in the nasalmucosa and IL-5 in NLF after single allergen challenge were partially attenuated in W/Wv mice. The levels of Af-specific IgEand IgG1 in both acute and chronic models were not different between W/Wv mice and W/W+ mice. Conclusion：These findingssuggest that eosinophilic inflammation caused by repeated allergen challenge are independent of mast cells in this AR model.(Korean J Otolaryngol 2006;49:912-7)

#비만세포·알레르기 비염·동물모델·Aspergillus. #Mast cell·Allergic rhinitis·Animal model·Aspergillus.

참고문헌 (19)

참고문헌 신청

/ 1995 / Mast cells modulate allergic pulmonary eosinophilia in mice 12 : 404 ~ 409

/ 1995 / T cells are necessary for Th2 cytokine production and eosinophilaccumulation in airways of antigen-challenged allergic mice 75 : 75 ~ 83

/ 1996 / Interleukin5 deficiency abolishes eosinophilia, airways hyperreactivity, and lungdamage in a mouse asthma model 183 : 195 ~ 201

/ 1996 / Role of mast cells eosinophilsand IL-5 in the development of airway hyperresponsivenessin sensitized mice 26 : 642 ~ 647

/ 1997 / Allergen-induced bronchial hyperreactivity and eosinophilicinflammation occur in the absence of IgE in a mouse modelof asthma 94 : 1344 ~ 1349

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