지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 84 - 95 (12page)
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초록· 키워드
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Objective : Ephedra sinica (ES) has has been used as remedy of allergic diseases for a long time in Korea. Inthe present study, we investigated the anti-allergic effects of ES on experimental allergic asthma mouse modelusing ovalbumin (OVA).
Methods : BALB/c mice were sensitized and challenged with 100 ug of OVA and 1 ㎎ of aluminum potassiumsulfate of 0.2 ㎖ phosphate-buffered saline(PBS) intraperitoneally on day 1 and 15. mice were challenged on 3consecutive days with 5% OVA and AHR was assessed 24 h after the last challenge. we examined the lunghistology, airway hyper sensitivity, total inflammatory cell count in bronchoaveloar lavage fluid(BALF),Th2-associated cytokines production and IgE production.
Results : ES potently inhibited the lung damage and the development of Penh. ES also reduced the number ofBAL cells during OVA-induced allergic asthma. Furthermore, ES inhibited cytokines production such as IL-4, IL-13productions, and IgE level of serum.
Conclusion : These results suggest that ES may inhibit the production of IL-4, IL-13, IgE and infiltration ofinflammatory cell and be beneficial oriental medicine for allergic asthma.
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