알레르기 마우스에서 황사가 비알레르기 반응에 미치는 영향

김선태; 이은정; 정주현; 강일규; 차흥억; 김대영; 도선희

추천

검색

자료유형: 학술저널

저자정보: 김선태 이은정 정주현 강일규 차흥억 김대영 도선희

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제6호

발행연도: 2009.1

수록면: 498 - 505 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives：Asian sand dust (ASD) is known to aggravate the respiratory symptoms in patients with bronchial asthma. However, the effect of ASD in allergic rhinitis is not known. The objective of this study was to investigate whether ASD can activate the allergic inflammation in allergic mouse model. Materials and Method：Forty female BALB/c mice were divided into 4 groups. Group 1 was nebulized with saline and group 2 with ASD. Group 3 was nebulized with ovalbumin (OVA) only and Group 4 with OVA plus ASD after intraperitoneal injection with OVA. The allergic symptom scores were checked. The mouse OVA specific IgE/IgG1, IL-4, IL-5 and IFN-γ were measured by ELISA. The nasal mucosa was examined for the expression of IL-4 and IL-5 by immunohistochemical stain. Results：The average symptom score was increased in Group 4 compared to Group 3 (p<0.05). The IgE was significantly increased in Group 4 compared to Group 3 (p<0.01). The IL-4 level of nasal lavagefluid (NALF) was significantly increased in Group 4 compared to Group 3 (p<0.05). The IL-5 level showed no significant difference between the Group 3 and Group 4 both in the serum and NALF. The level of IFN-γ was not changed in NALF. Immunohistochemical staining showed that the positive cells for IL-4 were expressed in epithelial layer and submucous gland and the positive cells were more increased in Group 4 than in Group 3. Conclusion：In allergic mouse model, ASD has shown to activate the allergic inflammatory reaction by the stimuli of Th2 cytokineproduction.

#황사·알레르기비염·사이토카인 #Asian sand dust·Allergic rhinitis·Cytokines

참고문헌 (24)

참고문헌 신청

Chen YS / 2004 / Effects of Asian dust storm events on daily mortality in Taipei, Taiwan / Environ Res 95 (2) : 151 ~ 155

Choi JC / 2001 / Chemical composition and source signature of spring aerosol in seoul / Korea J Geophys Res (106) : 18067 ~ 18074

Diaz-Sanchez D / 2000 / In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans / Clin Immunol

Donaldson K / 2001 / Ultrafine particles / Occup Environ Med 58 (3) : 211 ~ 216

Hong YC / 1999 / PM10 exposure, gaseous pollutants, and daily mortality in Inchon, Korea / Environ Health Perspect 107 (11) : 873 ~ 878

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!