반복적인 오존노출이 마우스에서 기도재형성에 미치는 영향

김용민; 김인중; 김효선; 김아영; 한욱경; 나기상

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자료유형: 학술저널

저자정보: 김용민 김인중 김효선 김아영 한욱경 나기상

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제3호

발행연도: 2008.1

수록면: 240 - 249 (10page)

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연구배경

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연구방법

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초록· 키워드

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To investigate whether repeated long-term exposure of ozone has an effect on airway remodeling and whether ozone exposure has an aggravating effect on airway remodeling during allergen challenge in previously sensitized mice. Materials and Method：Forty female BALB/c mice were divided into four groups as follows：Group I as the control group, Group II the ovalbumin aerosol exposure group, Group III the ozone exposure group, and Group IV the ovalbumin aerosol and ozone exposure group. Twenty-four hours after the last OVA challenge, the concentration of IFN-γ, IL-5, IL-13 and TGF-β and the count of eosinophil and lymphocyte were measured in nasal lavage fluid (NLF) and bronchoalvelolar lavage fluid (BALF). Immunohistochemical staining for MMP-9 and TIMP-1 were performed. Trichrome staining was also conducted to evaluate subepithelial fibrosis. Results：Group II and III exhibited increased IL-5, IL-13, and TGF-β in NLF and BALF, compared to Group I；Group IV showed more increased pattern for these cytokines, compared to Group II and III. Group II, III, and IV also showed increased expression of MMP-9 and TIMP-1, compared to Group I in lung；Group II and IV showed more compared to Group I and III in nasal cavity mucosa. Subepithelial fibrosis was prominent in Group II, III, and IV, compared with group I. In group IV, subepithelial fibrosis was more increased than Group II and III. Conclusion：These results suggest that ozone exposure induces remodeling in upper and lower airway and also enhances allergen-mediated airway remodeling in previously sensitized animals. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:240-9)

#Remodeling·Ozone·Allergic rhinitis.

참고문헌 (20)

참고문헌 신청

Bousquet J / 2004 / Allergic rhinitis: A disease remodeling the upper airways? / J Allergy Clin Immunol 113 (1) : 43 ~ 49

Chakir J / 199 / Lower airways remodeling in nonasthmatic subjects with allergic rhinitis / Lab Invest 75 (5) : 735 ~ 744

Chiaramonte MG / 1999 / An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response / J Clin Invest 104 (6) : 777

Douwes J / 2002 / Non-eosinophilic asthma: Importance and possible mechanisms / Thorax 57 (7) : 643 ~ 648

Gizycki MJ / 1997 / Myofibroblast involvement in the allergen-induced late response in mild atopic asthma / Am J Respir Cell Mol Biol 16 (6) : 664 ~ 673

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