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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제1호
- 발행연도
- 2017.1
- 수록면
- 64 - 67 (4page)
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초록· 키워드
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Objective: Prenatal infection is implicated in the etiology of schizophrenia. The objective of this paper is to study the role of complement protein C1q in the psychosis of adult offspring after maternal immune activation (MIA). In addition, effect of 7,8-dihydroxyflavone (7,8-DHF: a tropomyosin receptor kinase B [TrkB] agonist) was also examined.
Methods: Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(I:C) (5.0 mg/kg/day from E12 to E17) exposure was performed. 7,8-DHF or vehicle was given from 4 to 8-weeks old.
Results: Expression of C1q in the prefrontal cortex (PFC) of adult offspring from poly(I:C)-treated pregnant mice was significantly higher than that of control group. Early treatment with 7,8-DHF during juvenile and adolescent stages could prevent an increase of C1q in the PFC of adult offspring after MIA.
Conclusion: Therefore, it is likely that increased C1q expression in the frontal cortex may play a role in the behavioral abnormalities of adult offspring after MIA. Furthermore, supplementation with a TrkB agonist such as 7,8-DHF during the prodromal stage may have prophylactic effects on the behavioral abnormalities after MIA.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Agarwal V / 2015 / Roles of complement C1q in pneumococcus-host interactions / Crit Rev Immunol 35 : 173 ~ 184
Arakelyan A / 2011 / Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia / BMC Clin Pathol 11 : 10 ~
Brown AS / 2010 / Prenatal infection and schizophrenia : a review of epidemiologic and translational studies / Am J Psychiatry 167 : 261 ~ 280
Han M / 2016 / Intake of 7,8-dihydroxyflavone during juvenile and adolescent stages prevents onset of psychosis in adult offspring after maternal immune activation / Sci Rep
Jang SW / 2010 / A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone / Proc Natl Acad Sci U S A 107 : 2687 ~ 2692
Arakelyan A / 2011 / Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia / BMC Clin Pathol 11 : 10 ~
Brown AS / 2010 / Prenatal infection and schizophrenia : a review of epidemiologic and translational studies / Am J Psychiatry 167 : 261 ~ 280
Han M / 2016 / Intake of 7,8-dihydroxyflavone during juvenile and adolescent stages prevents onset of psychosis in adult offspring after maternal immune activation / Sci Rep
Jang SW / 2010 / A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone / Proc Natl Acad Sci U S A 107 : 2687 ~ 2692
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