지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 114 - 120 (7page)
이용수
초록· 키워드
오류제보하기
Objective: A number of epidemiological studies have reported that smoking causes a decrease in bone mineral density (BMD) and an increase in the risk of bone fracture, and is a risk factor for osteoporosis. Maternal smoking during pregnancy results in a variety of adverse developmental outcomes associated with intrauterine growth restriction. However, little is known about the effect of maternal smoking during pregnancy on BMD in the offspring. Methods: Pregnant CD-1 mice were exposed to cigarette smoke (1 or 2 cigarettes/day, 5 days/week) (smoke group) or sham exposed (control group) throughout pregnancy. After delivery, nursing dams and offspring were kept together in individual cages. At 4 weeks, the fourth lumbar vertebral body of each offspring was scanned with a micro- computed tomography apparatus. Trabecular parameters including bone volume fraction (bone volume/total volume, %), thickness (mm), number (1/mm), and separation (mm) were evaluated. The BMD was also measured. Results: No differences in the trabecular bone volume fraction, thickness, separation, and number and the BMD were observed between the offspring of the control and 1 cigarette smoking dams. However, trabecular bone volume fraction, thickness, number, and the BMD were significantly lower, whereas trabecular separation was higher in the offspring of 2 cigarette smoking dams compared with those of the offspring from control dams. Conclusion: Maternal smoking during pregnancy decreased BMD and altered bone microarchitecture in the offspring. These results will become a great source to inform the importance of quitting smoking during pregnancy.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Hodgson TA / 1992 / Cigarette smoking and lifetime medical expenditures / Milbank Q 70:81~125
Tsevat J / 1992 / Impact and cost-effectiveness of smoking interventions / Am J Med 93:43S~47S
Daniell HW / 1976 / Osteoporosis of the slender smoker. Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity / Arch Intern Med 136:298~304
Hopper JL / 1994 / The bone density of female twins discordant for tobacco use / N Engl J Med 330:387~392
Krall EA / 1999 / Smoking increases bone loss and decreases intestinal calcium absorption / J Bone Miner Res 14:215~220
Tsevat J / 1992 / Impact and cost-effectiveness of smoking interventions / Am J Med 93:43S~47S
Daniell HW / 1976 / Osteoporosis of the slender smoker. Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity / Arch Intern Med 136:298~304
Hopper JL / 1994 / The bone density of female twins discordant for tobacco use / N Engl J Med 330:387~392
Krall EA / 1999 / Smoking increases bone loss and decreases intestinal calcium absorption / J Bone Miner Res 14:215~220
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