Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model

Elvis Ngwa Ndonwi; Barbara Atogho-Tiedeu; Eric Lontchi-Yimagou; Tijjani S. Shinkafi; Dieudonne Nanfa; Eric V. Balti; Routray Indusmita; Amena Mahmood; Jean-Claude Katte; Armand Mbanya; Tandi Matsha; Jean Claude Mbanya; Ali Shakir; Eugene Sobngwi

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저자정보: Elvis Ngwa Ndonwi (University of Yaoundé 1) Barbara Atogho-Tiedeu (University of Yaoundé 1) Eric Lontchi-Yimagou (Albert Einstein College of Medicine) Tijjani S. Shinkafi (Jamia Hamdard Deemed University) Dieudonne Nanfa (University of Yaoundé 1) Eric V. Balti (Brussels Free University-VUB) Routray Indusmita (Jamia Hamdard Deemed University) Amena Mahmood (Jamia Hamdard Deemed University) Jean-Claude Katte (Yaoundé Central Hospital) Armand Mbanya (Albert Einstein College of Medicine) Tandi Matsha (Cape Peninsula University of Technology) Jean Claude Mbanya (University of Yaoundé 1) Ali Shakir (Usmanu Danfodiyo University Sokoto) Eugene Sobngwi (University of Yaoundé 1)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.3

발행연도: 2019.7

수록면: 241 - 248 (8page)

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Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin of health and disease, putative trans-generational effect of exposure to pesticides are insufficiently studied. We therefore aimed to evaluate the biochemical effect of gestational exposure to four pesticides on female Wistar rats and their offspring at adult age. We studied 30 female nulliparous Wistar rats divided into 5 equal groups. Group 1 served as the control group and received distilled water while group 2, 3, 4 and 5 received orally pesticide 1 (imidacloprid), pesticide 2 (chlorpyrifos), pesticide 3 (imidacloprid + lambda cyhalothrin) and pesticide 4 (oxamyl) respectively once daily throughout gestation at a dose equivalent to 1/10 lethal dose 50. The mothers were followed up until one month post gestation. The offspring were followed up from birth until adult age (12 weeks). In all animals at each time point we evaluated malondialdehyde (MDA), oxidative stress and liver function enzymes. There was similar variation of total body weight in all the groups during and after gestation. However, Female Wistar rats of the exposed groups had significant alterations in liver SOD (-30.8% to +64.1%), catalase (-38.8% to -85.7%) and GSH (-29.2% to -86.5%) and; kidney catalase (> 100%), GSH (> 100%). Moreover, MDA, alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly higher in pesticide exposed rats compared to the control group. Similar alterations in antioxidant enzymes, MDA and liver function enzymes were observed in offspring of treated rats evidenced at weaning and persisting until adult age. Exposure to pesticides causes oxidative stress and lipid peroxidation in exposed female Wistar rats and their offspring. The persistence in offspring at adult age suggests transgenerational adverse effects.

#Foetal exposure #Insecticide #Biochemical alterations #Offspring #Adult age

참고문헌 (39)

참고문헌 신청

Ming, Y. / 2013 / Occupational pesticide exposures and respiratory health / Int. J. Environ. Res. Public Health 10:6442~6471

신한재 / 2017 / Comparative In Vitro Biological Toxicity of Four Kinds of Air Pollution Particles / 한국독성학회지 33(4):305~313

Food and Agriculture Organization of the United Nations / Database on Pesticides Consumption

Clark, J.M. / 2007 / Pyrethroid action on calcium channels. Neurotoxicological implications / Invert. Neurosci 7:3~16

Nagata, K. / 1998 / Modulation of the neuronal nicotinic acetylcholine receptorchannel by the nitromethylene heterocycle imidacloprid / J. Pharmacol. Exp. Ther 285:731~738

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