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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 85 - 91 (7page)
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Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent complications of diabetes, affect sensory, motor, and autonomic nerves. This study aimed to investigate whether 7,8-dihydroxyflavone (7,8-DHF) protects SH-SY5Y neuronal cells against high glucose-induced toxicity. In the current study, we found that diabetic patients exhibited higher lipid peroxidation caused by oxidative stress than healthy subjects. 7,8-DHF exhibits superoxide anion and hydroxyl radical scavenging activities. High glucose-induced toxicity severely damaged SH-SY5Y neuronal cells, causing mitochondrial depolarization; however, 7,8-DHF recovered mitochondrial polarization. Furthermore, 7,8-DHF effectively modulated the expression of pro-apoptotic protein (Bax) and anti-apoptotic protein (Bcl-2) under high glucose, thus inhibiting the activation of caspase signaling pathways. These results indicate that 7,8-DHF has antioxidant effects and protects cells from apoptotic cell death induced by high glucose. Thus, 7,8-DHF may be developed into a promising candidate for the treatment of diabetic neuropathy.
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참고문헌 (34)
참고문헌 신청
Anil Kumar D / 2018 / Proteomic Changes in Chick Brain Proteome Post Treatment with Lathyrus Sativus Neurotoxin, β-N-Oxalyl-L-α,β-Diaminopropionic Acid (L-ODAP): A Better Insight to Transient Neurolathyrism / 한국독성학회지 34(3):267~279
Babizhayev MA / 2015 / The role of oxidative stress in diabetic neuropathy : generation of free radical species in the glycation reaction and gene polymorphisms encoding antioxidant enzymes to genetic susceptibility to diabetic neuropathy in population of type I diabetic patients / Cell Biochem. Biophys 71:1425~1443
Barski OA / 2008 / The aldo-keto reductase superfamily and its role in drug metabolism and detoxification / Drug Metab. Rev 40:553~624
Berrone E / 2006 / Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose / J. Biol. Chem 281:9307~9313
Brownlee M / 2005 / The pathobiology of diabetic complications : a unifying mechanism / Diabetes 54:1615~1625
Babizhayev MA / 2015 / The role of oxidative stress in diabetic neuropathy : generation of free radical species in the glycation reaction and gene polymorphisms encoding antioxidant enzymes to genetic susceptibility to diabetic neuropathy in population of type I diabetic patients / Cell Biochem. Biophys 71:1425~1443
Barski OA / 2008 / The aldo-keto reductase superfamily and its role in drug metabolism and detoxification / Drug Metab. Rev 40:553~624
Berrone E / 2006 / Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose / J. Biol. Chem 281:9307~9313
Brownlee M / 2005 / The pathobiology of diabetic complications : a unifying mechanism / Diabetes 54:1615~1625
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