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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제8권 제3호
- 발행연도
- 2010.1
- 수록면
- 137 - 143 (7page)
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초록· 키워드
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Objective: In this study, authors wanted to find out the association between the glycogen synthase kinase-3β (GSK-3β) −50T/C polymorphism and depression and cognitive impairment in patients with schizophrenia. 207 schizophrenia and 100 normal subjects were participated. We evaluated Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale (HAM-D), and the Korean version of the Mini Mental Status Examination (K-MMSE) in schizophrenia.
Methods: Polymerase chain reaction (PCR) analysis of genomic DNA was conducted to evaluate the genotype distribution and allele frequency of GSK-3β −50T/C in subjects.
Results: We observed that genotype distribution and allele frequency were not significantly different between schizophrenia and normal subjects. Moreover, no significant difference was found in the promoter polymorphism of GSK-3β in compound genotype distributions and allele frequencies in schizophrenia according to HAM-D scores. However, there was a difference in genotype distribution and allele frequency in schizophrenia according to cognitive impairment.
Conclusion: These results suggest that the GSK-3β −50T/C gene polymorphism may be associated with cognitive impairment in patients with schizophrenia.
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참고문헌 (26)
참고문헌 신청
Angelucci F / 2005 / BDNF in schizophrenia, depression and corresponding animal models / Mol Psychiatry 10 : 345 ~ 352
Arnold SE / 1999 / Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology / Dev Psychopathol 11 : 439 ~ 456
Benedetti F / 2004 / A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation i
Benedetti F / 2004 / A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder /
Benedetti F / 2005 / Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta ?50 T/C SNP / Neurosci Lett 376 : 51 ~ 55
Arnold SE / 1999 / Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology / Dev Psychopathol 11 : 439 ~ 456
Benedetti F / 2004 / A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation i
Benedetti F / 2004 / A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder /
Benedetti F / 2005 / Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta ?50 T/C SNP / Neurosci Lett 376 : 51 ~ 55
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