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자료유형
학술저널
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저널정보
대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제39권 제2호
발행연도
2009.1
수록면
269 - 278 (10page)

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Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status. Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by χ² test. Results: There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position -519 of MMP-1 gene promoter (P <0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P <0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P <0.05). Conclusions: The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.(J Korean Acad Periodontol 2009;39:269-278)

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