메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Recommendations
Search

논문 기본 정보

Type
Academic journal
Author
Journal
Korean Society of Obstetrics and Gynecology Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제62권 제3호 KCI Accredited Journals
Published
2019.1
Pages
157 - 165 (9page)

Usage

cover
Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Ask AI
Recommendations
Search

Abstract· Keywords

Report Errors
ObjectiveThis study aimed to analyze the expression pattern of glycogen synthase kinase 3β (GSK3β) and its phosphorylatedforms, GSK3β phosphorylated at Ser9 (pS9GSK3β), and GSK3β phosphorylated at Tyr216 (pY216GSK3β), in cervicalsquamous cell carcinoma (SCC) and adenocarcinoma (AC). MethodsWe performed immunohistochemical staining for GSK3β, pS9GSK3β, and pY216GSK3β in 64 SCC and 20 AC cases andcompared their expression patterns between the 2 tumor types. ResultsIncreased GSK3β and pS9GSK3β expression but decreased pY216GSK3β expression compared with that in the normalcervix were observed in both SCC and AC specimens. Specifically, the levels of GSK3β and pS9GSK3β were significantlyincreased in SCC and AC, respectively. GSK3β was localized in the nucleus and/or cytoplasm of SCC and AC cells. However, pS9GSK3β was predominantly localized in the membrane of AC cells, whereas it was present in the nucleusand/or cytoplasm of SCC cells. ConclusionThe results suggest that the phosphorylation status of GSK3β changes during cervical cancer development and thedifferent expression levels and patterns of GSK3β and pS9GSK3β are associated with the specific histologic phenotypeof cervical cancer.

Contents

No content found

References (34)

Add References
Wang SS / 2004 / Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000 / Cancer 100:1035~1044 google schola Green J / 2003 / Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years : the UK National Case-Control Study of Cervical Cancer / Br J Cancer 89:2078~2086 google schola Bertelsen BI / 2006 / Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia : frequent PIK3CA amplification and AKT phosphorylation / Int J Cancer 118:1877~1883 google schola Pett MR / 2004 / Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes / Cancer Res 64:1359~1368 google schola Duensing S / 2003 / Centrosomes, genomic instability, and cervical carcinogenesis / Crit Rev Eukaryot Gene Expr 13:9~23 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

Instruction Model for Elementary School on Programming Induction Education Using ENTRY
Eun Hyeong Lee, Tae Wuk LeeThe Korean Association Of Computer Education2015.01
 기업과 재무위험 관리
이태규management & economic research institute1999.12
 Symbol Representing the Korean Victims Fallen at Okinawa and the Potential Use of Such Symbol in Peace Education
Yamaguchi TakeshiThe Korean Society for Urban History2014.06
 박윤덕, 『시민 혁명』(책세상, 2010), 154쪽
윤승준SociÉTÉ CorÉEnne DHistoire FranÇAise2011.02

Comments(0)

0

Write first comments.