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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 202 - 207 (6page)
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초록· 키워드
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ObjectiveaaGlycogen synthase kinase-3β (GSK-3β) has become recognized as a broadly influential enzyme affecting diverse range of biological functions, including gene expression, cellular architecture, and apoptosis. The results of previous studies suggest that GSK-3β activity may be increased in the brain of patients with major depressive disorders (MDD). A recent animal study reported increased GSK-3β messenger ribonucleic acid (mRNA) level in the hippocampus of those with depression. However, few studies have investigated GSK-3β activity in the brain of patients with MDD.
MethodsaaIn order to test whether patients with MDD have an increase in GSK-3β activity in the brain compared to normal controls, we explored GSK-3β expression level in all brain regions by using the Stanley Neuropathology Consortium Integrative Database (SNCID), which is a web-based method of integrating the Stanley Medical Research Institute data sets.
ResultsaaThe level of GSK-3β mRNA expression in the hippocampus was significantly increased in the MDD group (n=8) compared with the control group (n=12, p<0.05). Spearman’s test also reveals that GSK-3β mRNA expression levels were significantly correlated with nitric oxide synthase 1 (NOS1)(ρ=0.70, p<0.0001) and stathmin-like 3 (STMN3)(ρ=0.70, p<0.0001) in the hippocampus.
ConclusionaaOur results correspond with the results of previous animal studies that reported increased GSK-3β activity in the hippocampus of those with depression. Our findings also suggest that oxidative stress-induced neuronal cell death and abnormal synaptic plasticity in the hippocampus may play important roles in the pathophysiology of major depression.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Andoh T / 2000 / Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress / FASEB 14 : 2144 ~ 2146
Beurel E / 2006 / The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways / Prog Neurobiol 79 : 173 ~ 189
Calabrese V / 2007 / Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity / Nat Rev Neurosci 8 : 766 ~ 775
Embi N / 1980 / Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase / Eur J Biochem 107 : 519
Gould TD / 2004 / AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test / Int J Neuropsychopharmacol 7 : 387 ~ 390
Beurel E / 2006 / The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways / Prog Neurobiol 79 : 173 ~ 189
Calabrese V / 2007 / Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity / Nat Rev Neurosci 8 : 766 ~ 775
Embi N / 1980 / Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase / Eur J Biochem 107 : 519
Gould TD / 2004 / AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test / Int J Neuropsychopharmacol 7 : 387 ~ 390
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