지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 65 - 76 (12page)
이용수
초록· 키워드
오류제보하기
Objectives : In the central nervous system. apolipoprotein E(Apo E) is thought to playa role in neuronal growth and repair. Numerous studies have provided evidence for a genetic association of the Apo E ε4 allele and late onset familial and sporadic Alzheimer's disease. However, previous studies on Apo E genotype distribution in schizophrenia, which would suffer from severe cognitive impairment. have reported conflicting findings. So we have examined the genetic association between schizophrenia and Apo E genotype polymorphism to investigate the possible contribution to schizophrenia.
Methods : Genomic DNAs from 100 schizophrenic patients and 60 healthy controls were isolated. The Apo E genotype was determined by the polymerase chain reaction (PCR) with sequence-specific oligonucleotide primers (SSOP) and reverse hybridization using the INNO LiPA(Line Probe Assay) Apo E typing test kit. The frequencies of allele and genotype were compared between patients and controls. And the allele frequencies were compared in terms of positive and negative subtypes according to the PANSS, family history and age of onset.
Results : The frequencies of Apo E allele and genotype were not signilicantly different between the patients and controls. But in patients group, the frequencies of allele and genotype between subtypes by PANSS were significantly different. Some other clinical variables such as sex, age of onset and family history were not associated with Apo E genotype.
Conclusion : Apo E gene has no causal relation to the development of schizophrenia in Korean population, but it may affect the phenotype of schizophrenia.
Methods : Genomic DNAs from 100 schizophrenic patients and 60 healthy controls were isolated. The Apo E genotype was determined by the polymerase chain reaction (PCR) with sequence-specific oligonucleotide primers (SSOP) and reverse hybridization using the INNO LiPA(Line Probe Assay) Apo E typing test kit. The frequencies of allele and genotype were compared between patients and controls. And the allele frequencies were compared in terms of positive and negative subtypes according to the PANSS, family history and age of onset.
Results : The frequencies of Apo E allele and genotype were not signilicantly different between the patients and controls. But in patients group, the frequencies of allele and genotype between subtypes by PANSS were significantly different. Some other clinical variables such as sex, age of onset and family history were not associated with Apo E genotype.
Conclusion : Apo E gene has no causal relation to the development of schizophrenia in Korean population, but it may affect the phenotype of schizophrenia.
목차
서론
연구대상 및 방법
결과
고찰
참고문헌
참고문헌 (92)
참고문헌 신청
1. [학술지(정기간행물)] - Adityanjee / 1999 / Dementia praecox to schizophrenia: the first 100 years / Psychiatry Clin Neurosci 53 : 437 ~ 448
2. [학술지(정기간행물)] - Hoff AL / 2005 / Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia / Schizophrenia Res 78 : 27 ~ 34
3. [학술지(정기간행물)] - Tollefson GD / 1996 / Cognitive function in schizophrenic patients / J Clin Psychiatry 57 (suppl 11) : 31 ~ 39
4. [학술지(정기간행물)] - Goldberg TE / 1996 / Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies / J Clin Psychiatry 57 (suppl 9) : 62 ~ 65
5. [학술지(정기간행물)] - Strittmatter WJ / 1993 / Apolipoprotein E: High avidity binding to beta amyloid and increased frequency of type 4 allele in late onset familial Alzheimer disease / Proc Nat Acad Sci USA 90 : 1977 ~ 1981
2. [학술지(정기간행물)] - Hoff AL / 2005 / Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia / Schizophrenia Res 78 : 27 ~ 34
3. [학술지(정기간행물)] - Tollefson GD / 1996 / Cognitive function in schizophrenic patients / J Clin Psychiatry 57 (suppl 11) : 31 ~ 39
4. [학술지(정기간행물)] - Goldberg TE / 1996 / Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies / J Clin Psychiatry 57 (suppl 9) : 62 ~ 65
5. [학술지(정기간행물)] - Strittmatter WJ / 1993 / Apolipoprotein E: High avidity binding to beta amyloid and increased frequency of type 4 allele in late onset familial Alzheimer disease / Proc Nat Acad Sci USA 90 : 1977 ~ 1981
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