지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 180 - 189 (10page)
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Purpose High proliferation rate is a hallmark of cancer. The mitotic index is a useful and simple method for analysis of cell proliferation. However, the practical utility of mitotic index as a predictor of prognosis in patients with hepatocellular carcinoma (HCC) has not been deter- mined. Therefore, we examined mitotic index as a prognostic marker in HCC patients.
Materials and Methods We counted the number of mitotic cells in 10 high-power fields of the tumor area on hema- toxylin and eosin–stained slides representing 282 surgically resected HCCs. The highest number of mitotic cells was defined as the mitotic index.
Results High mitotic index was observed in 127 of 282 HCCs. High mitotic index showed significant association with younger age, larger tumor size, higher Edmondson grade, microvascular invasion, major portal vein invasion, intrahepatic metastasis, higher American Joint Com- mittee on Cancer (AJCC) T-stage, higher Barcelona Clinic Liver Cancer (BCLC) stage, higher alpha-fetoprotein level, hepatitis B virus etiology, and liver cirrhosis. Patients with high mitotic index had shorter disease-specific survival (DSS) (p < 0.001) and tended to have shorter recurrence-free survival (p=0.112). In subgroup analysis among patients with a larger tumor size, microvascular invasion, intrahepatic metastasis, higher AJCC T-stage, and higher BLCL stage, high mitotic index showed unfavorable influences on DSS (p=0.001, p=0.008, p=0.003, p=0.012, and p < 0.001, respectively). In addition, high mitotic index was an independent predictor of shorter DSS (p=0.004).
Conclusion High mitotic index may be a novel predictor of DSS in patients with HCC and may have utility as an auxiliary prognostic factor in HCC.
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참고문헌 (20)
참고문헌 신청
Okuda K / 1985 / Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850patients / Cancer 56:918~928
Llovet JM / 2005 / Resection and liver transplantation for hepatocellular carcinoma / Semin Liver Dis 25:181~200
Poon RT / 2011 / Prevention of recurrence after resection of hepatocellular carcinoma : a daunting challenge / Hepatology 54:757~759
Hanahan D / 2000 / The hallmarks of cancer / Cell 100:57~70
Ouchi K / 2000 / Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma / Dig Surg 17:42~48
Llovet JM / 2005 / Resection and liver transplantation for hepatocellular carcinoma / Semin Liver Dis 25:181~200
Poon RT / 2011 / Prevention of recurrence after resection of hepatocellular carcinoma : a daunting challenge / Hepatology 54:757~759
Hanahan D / 2000 / The hallmarks of cancer / Cell 100:57~70
Ouchi K / 2000 / Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma / Dig Surg 17:42~48
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