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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제1호
- 발행연도
- 2015.1
- 수록면
- 23 - 29 (7page)
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Background: Counting mitoses is subjective and time-consuming. The adjunctive diagnostic utility of a recently reported mitotic marker, phosphohistone H3 (PHH3), was investigated in gastrointestinal stromal tumors (GISTs). Methods: We reviewed 77 GISTs for several proliferative indices. These included the mitotic count per 50 high power fields (HPFs), the immunohistochemical Ki-67 labeling index and the immunohistochemical PHH3 mitotic index (MI). For comparison, Spearman’s rank correlation and interclass correlation coefficient were used. Results: Mitotic counts ranged from 0–138 (mean, 7.57±2.34) and the PHH3 MI ranged from 0–126 per 50 HPFs (mean, 9.61±2.27). We found a positive correlation between mitotic counts and PHH3 MI (r=0.810, p<.001). The inter-observer correlation coefficient for three participants was 0.975 for mitotic counts and 0.940 for the PHH3 MI. When using the PHH3 MI instead of mitotic counts in the Armed Forces Institute of Pathology (AFIP) stratification criteria, 10 cases were reclassified. In one patient with a mitotic count of 2 and a PHH3 MI of 6 per 50 HPFs, distant metastasis occurred. Conclusions: In GISTs, the PHH3 MI correlated adequately with mitotic counts and can be used as a useful adjunctive to count mitotic figures efficiently.
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참고문헌 (21)
참고문헌 신청
Agaimy A / 2010 / Gastrointestinal stromal tumors (GIST) from risk stratification systems to the new TNM proposal: more questions than answers? A review emphasizing the need
Bossard C / 2006 / Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index / J Clin Pathol 59
Carrillo R / 1997 / Prognostic significance of DNA ploidy and proliferative index(MIB-1 index)in gastrointestinal stromal tumors / Hum Pathol 28 : 160 ~ 165
Corless CL / 2004 / Biology of gastrointestinal stromal tumors / J Clin Oncol 22 : 3813 ~ 3825
Fletcher CD / 2002 / Diagnosis of gastrointestinal stromal tumors: a consensus approach / Hum Pathol 33 : 459 ~ 465
Bossard C / 2006 / Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index / J Clin Pathol 59
Carrillo R / 1997 / Prognostic significance of DNA ploidy and proliferative index(MIB-1 index)in gastrointestinal stromal tumors / Hum Pathol 28 : 160 ~ 165
Corless CL / 2004 / Biology of gastrointestinal stromal tumors / J Clin Oncol 22 : 3813 ~ 3825
Fletcher CD / 2002 / Diagnosis of gastrointestinal stromal tumors: a consensus approach / Hum Pathol 33 : 459 ~ 465
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