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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 388 - 396 (9page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaMajor depressive disorder (MDD) is a common mood disorder associated with several psychophysiological changes like disturbances of sleep, appetite, or sexual desire, and it affects the patients’ life seriously. We aimed to explore a genetic method to investigate the mechanism of MDD.
MethodsaaThe mRNA expression profile (GSE53987) of MDD was downloaded from Gene Expression Omnibus database, including 105 samples of three brain regions in post-mortem tissue suffered from MDD and unaffected controls. Differentially expressed genes (DEGs) in MDD were identified using the Limma package in R. Gene Ontology functions and Kyoto Enrichment of Genes and Genomes pathways of the selected DEGs were enriched using Database for Annotation, Visualization and Integrated Discovery. Protein-protein interactive network of DEGs was constructed using the Cytoscape software.
ResultsaaTotally, 241 DEGs in MDD-hip group, 218 DEGs in MDD-pfc group, and 327 DEGs in MDD-str group were identified. Also, different kinds of biological processes of DEGs in each group were enriched. Besides, glycan biosynthesis of DEGs in MDD-str group, RIG-I-like receptor signaling and pyrimidine metabolism of DEGs in the MDD-hip group were enriched, respectively. Moreover, several DEGs like PTK2, TDG and CETN2 in MDD-str group, DCT, AR and GNRHR in MDD-pfc group, and AKT1 and IRAK1 in MDD-hip group were selected from PPI network.
ConclusionaaOur data suggests that the brain striatum tissue may be greatly affected by MDD, and DEGs like PTK2, GALNT2 and GALNT2 in striatum, AR in prefrontal cortex and IRAK1 and IL12A in hippocampus may provide novel therapeutic basis for MDD treatment.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Barrett T / 2006 / Gene expression omnibus: microarray data storage, submission, retrieval, and analysis / Methods Enzymol 411 : 352 ~ 369
Barrett T / 2007 / NCBI GEO: mining tens of millions of expression profiles-database and tools update / Nucleic Acids Res 35 : D760 ~ D765
Beck AT / 2009 / Depression: Causes and Treatment / University of Pennsylvania Press
Belmaker R / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Boldrini M / 2013 / Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression / Neuropsychopharmacology 38 : 1068 ~
Barrett T / 2007 / NCBI GEO: mining tens of millions of expression profiles-database and tools update / Nucleic Acids Res 35 : D760 ~ D765
Beck AT / 2009 / Depression: Causes and Treatment / University of Pennsylvania Press
Belmaker R / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Boldrini M / 2013 / Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression / Neuropsychopharmacology 38 : 1068 ~
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