지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제2호
- 발행연도
- 2017.1
- 수록면
- 100 - 114 (15page)
이용수
초록· 키워드
오류제보하기
The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial effects. The enzyme glycogen synthase kinase 3 (GSK3) has come into focus, as lithium and several other mood stabilizing medications inhibit its activity.
This kinase and its key upstream modulator, Wnt are dysregulated in mood disorders and there is a growing impetus to delineate the chief substrates involved in the development of these illnesses. In May 2016, a comprehensive literature search was undertaken which revealed that there is over activity of GSK3 in bipolar disorder with deleterious downstream effects like proinflammatory status, increased oxidative stress, and circadian dysregulation leading to declining neurotrophic support and enhanced apoptosis of neural elements. By developing specific GSK3 inhibitors the progressive worsening in bipolar disorder can be forestalled with improved prospects for the sufferers.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Machado-Vieira R / 2009 / The role of lithium in the treatment of bipolar disorder : convergent evidence for neurotrophic effects as a unifying hypothesis / Bipolar Disord 11(Suppl 2):92~109
Ferensztajn-Rochowiak E / 2016 / The effect of lithium on hematopoietic, mesenchymal and neural stem cells / Pharmacol Rep 68:224~230
Hussaini SM / 2014 / Wnt signaling in neuropsychiatric disorders : ties with adult hippocampal neurogenesis and behavior / Neurosci Biobehav Rev 47:369~383
Ather Muneer / 2016 / Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers / PSYCHIATRY INVESTIGATION 13(1):18~33
Ajmone-Cat MA / 2016 / Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells / Brain Behav Immun 55:225~235
Ferensztajn-Rochowiak E / 2016 / The effect of lithium on hematopoietic, mesenchymal and neural stem cells / Pharmacol Rep 68:224~230
Hussaini SM / 2014 / Wnt signaling in neuropsychiatric disorders : ties with adult hippocampal neurogenesis and behavior / Neurosci Biobehav Rev 47:369~383
Ather Muneer / 2016 / Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers / PSYCHIATRY INVESTIGATION 13(1):18~33
Ajmone-Cat MA / 2016 / Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells / Brain Behav Immun 55:225~235
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Staging Models in Bipolar Disorder: A Systematic Review of the Literature
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Disruptive Mood Dysregulation Disorder & Bipolar disorder (BD)
대한소아청소년정신의학회 학술대회논문집
2022 .05
-
알코올 사용 장애에서 양극성 장애 선별 질문지들의 타당성 및 임상적 유용성 비교를 위한 예비연구
우울조울병
2016 .01
-
Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update
Clinical Psychopharmacology and Neuroscience
2015 .01
-
양극성장애에서의 공존 불안
대한불안의학회지
2024 .04
-
Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Obstetrics & Gynecology Science
2019 .01
-
안정기 1형 양극성장애 환자의 자가보고 공감 반응 : 조현병 환자 및 정상인과의 비교
우울조울병
2016 .01
-
한국형 양극성 장애 약물치료 알고리듬 2018 : 노인
우울조울병
2018 .01
-
20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3b in the Wnt/ GSK-3b/b-catenin pathway
Journal of Ginseng Research
2020 .05
-
The Influence of Current Mood States on Screening Accuracy of the Mood Disorder Questionnaire
Clinical Psychopharmacology and Neuroscience
2020 .01
-
양극성 I형 장애 환자와 발병하지 않은 일차 친족에서 인지조절의 비교
생물정신의학
2018 .01
-
양극성장애 환자용 한국어판 기분 기록 스마트폰어플리케이션의 개발 및 임상적 적용
신경정신의학
2018 .01
-
Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers
PSYCHIATRY INVESTIGATION
2016 .01
-
신경 발달 장애에서 정신병 혹은 양극성 장애로의 전환 확률
대한조현병학회지
2022 .10
-
Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers
Clinical Psychopharmacology and Neuroscience
2022 .05
-
Natural Products Targeting Wnt/β-catenin Signaling Pathway
Natural Product Sciences
2020 .06
-
우울장애 환자군과 양극성장애 환자군의 인지기능 차이와 변별 : K-WAIS, Rey-Kim 기억검사, Kims 전두엽-관리기능검사의 수행패턴을 중심으로
생물치료정신의학
2015 .02
-
Simultaneous Utilization of Mood Disorder Questionnaire and Bipolar Spectrum Diagnostic Scale for Machine Learning-Based Classification of Patients With Bipolar Disorders and Depressive Disorders
PSYCHIATRY INVESTIGATION
2024 .08
-
한국형 양극성 장애 약물치료 알고리듬 2018 : 신체 질환이 동반되었을 경우
우울조울병
2018 .01
-
한국형 양극성 장애 약물치료 알고리듬 2022: 노인
신경정신의학
2022 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0