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논문 기본 정보
- 자료유형
- 학술저널
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- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 121 - 128 (8page)
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The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases phosphorylation levels of these proteins in the nucleus accumbens (NAcc), an important neuronal substrate mediating rewarding effects of drugs of abuse. In the present study, we further examined what molecular pathways may be involved in this process. By direct microinjection of LY294002, a PI3 kinase inhibitor, or of S9 peptide, a proposed GSK3β activator, into the NAcc core, we found that phosphorylation levels of ERM as well as of GSK3β in this site are simultaneously decreased. These results indicate that ERM proteins are under the regulation of Akt-GSK3β signaling pathway in the NAcc core. The present findings have a significant implication to a novel signal pathway possibly leading to structural plasticity in relation with drug addiction.
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참고문헌 (32)
참고문헌 신청
Bretscher A / 2002 / ERM proteins and merlin : integrators at the cell cortex / Nat Rev Mol Cell Biol 3:586~599
Louvet-Vallée S / 2000 / ERM proteins : from cellular architecture to cell signaling / Biol Cell 92:305~316
Niggli V / 2008 / Ezrin/radixin/moesin : versatile controllers of signaling molecules and of the cortical cytoskeleton / Int J Biochem Cell Biol 40:344~349
Pelaseyed T / 2018 / Regulation of actin-based apical structures on epithelial cells / J Cell Sci 131:jcs221853
Matus A / 2005 / Growth of dendritic spines : a continuing story / Curr Opin Neurobiol 15:67~72
Louvet-Vallée S / 2000 / ERM proteins : from cellular architecture to cell signaling / Biol Cell 92:305~316
Niggli V / 2008 / Ezrin/radixin/moesin : versatile controllers of signaling molecules and of the cortical cytoskeleton / Int J Biochem Cell Biol 40:344~349
Pelaseyed T / 2018 / Regulation of actin-based apical structures on epithelial cells / J Cell Sci 131:jcs221853
Matus A / 2005 / Growth of dendritic spines : a continuing story / Curr Opin Neurobiol 15:67~72
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