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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제6호
- 발행연도
- 2018.1
- 수록면
- 363 - 368 (6page)
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Background: Vitiligo is a chronic autoimmune disease in which the destruction of melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK–signal transducer and activator of transcription pathway. The aim of the present study is to explore the possible role of JAK1 in the pathogenesis of vitiligo using immunohistochemical methods. Methods: The current study was conducted in a sample of 39 patients who presented with vitiligo and 22 healthy individuals who were age and sex matched as a control group. We used immunohistochemistry to evaluate JAK1 status (intensity and distribution) and assess the percentage of residual melanocytes using human melanoma black 45 (HMB45). Results: Intense and diffuse JAK1 expression was significantly more likely to indicate vitiliginous skin compared to normal skin (p < .001). Strong and diffuse JAK1 expression was associated with short disease duration, female sex, and lower percentage of melanocytes (detected by HMB45) (p < .05). Conclusions: JAK1 may be involved in the pathogenesis of vitiligo, as indicated by intense and diffuse expression compared to control and association with lower percentage of melanocytes detected by HMB45 immunostaining.
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참고문헌 (16)
참고문헌 신청
Bonotis K / 2016 / Investigation of factors associated with health-related quality of life and psychological distress in vitiligo / J Dtsch Dermatol Ges 14:45~49
Bhise SB / 2004 / Role of protein tyrosine kinase inhibitors in cancer therapeutics / Indian J Biochem Biophys 41:273~280
Rane SG / 2000 / Janus kinases: components of multiple signaling pathways / Oncogene 19:5662~5679
Basak PY / 2008 / Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometric study / J Eur Acad Dermatol Venereol 22:970~976
van den Boorn JG / 2009 / Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients / J Invest Dermatol 129:2220~2232
Bhise SB / 2004 / Role of protein tyrosine kinase inhibitors in cancer therapeutics / Indian J Biochem Biophys 41:273~280
Rane SG / 2000 / Janus kinases: components of multiple signaling pathways / Oncogene 19:5662~5679
Basak PY / 2008 / Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometric study / J Eur Acad Dermatol Venereol 22:970~976
van den Boorn JG / 2009 / Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients / J Invest Dermatol 129:2220~2232
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