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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 79 - 81 (3page)
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Dear Editor, Translocation t(8;9)(p22;p24) has been reported in diverse hematologic neoplasms, including acute leukemia, myeloproliferative neoplasm (MPN), and myelodysplastic syndromes/myeloproliferative neoplasm. These findings indicate that the mutation occurs in pluripotent, lymphoid-myeloid stem cells [1]. The pericentriolar material 1 (PCM1) gene, located on chromosome 8p22, encodes a protein with coiled-coil domains, and the Janus activated kinase 2 (JAK2) gene, located on chromosome 9p24, encodes non-receptor tyrosine kinases [2, 3]. The t(8;9)(p22;p24) leads to a PCM1-JAK2 fusion gene, resulting in the continuous activation of JAK2 tyrosine kinase [2]. Here we report a case of myeloid sarcoma (MS) and concurrent myeloproliferative neoplasm, unclassifiable (MPN, U), associated this translocation.
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참고문헌 (8)
참고문헌 신청
Bain BJ / 2014 / Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities? / Br J Haematol 166:809~817
Patterer V / 2013 / Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 / Ann Hematol 92:759~769
Saba N / 2013 / A myeloproliferative neoplasm with translocation t(8;9)(p22;p24) involving JAK2 gene / Blood 122:861
Bousquet M / 2005 / The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene / Oncogene 24:7248~7252
Reiter A / 2005 / The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2 / Cancer Res 65:2662~2667
Patterer V / 2013 / Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 / Ann Hematol 92:759~769
Saba N / 2013 / A myeloproliferative neoplasm with translocation t(8;9)(p22;p24) involving JAK2 gene / Blood 122:861
Bousquet M / 2005 / The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene / Oncogene 24:7248~7252
Reiter A / 2005 / The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2 / Cancer Res 65:2662~2667
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