지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Rheumatoid arthritis is a chronic inflammatory destructive disorder that affects the joints, muscles, and tendons accompanying various extra-articular manifestations. Traditional disease-modifying anti-rheumatic drugs (DMARDs) represent the basic treatment for rheumatoid arthritis. Over the last 20 years, biologic DMARDs (tumor necrosis factor inhibitors, interleukin-1 inhibitors, interleukin-6 inhibitors, T cell inhibitors, and B cell inhibitors) have been widely used as a novel class of DMARDs that have efficacy and efficiency. Discovery of the underlying pathogenesis of autoimmune disease enables us to develop new target therapies such as a Janus kinase (JAK) inhibitor. Activated JAK is known to activate signal transducers as well as activators of transcription (STAT) signaling. A JAK inhibitor is a type of medication that functions by inhibiting the JAK-STAT signaling pathway. In addition, it is easy to take a JAK inhibitor orally. In Korea, several JAK inhibitors have been approved. This review describes the types of JAK inhibitors, recommended doses, side effects, and updated European Alliance of Associations for Rheumatology guidelines. Clinicians should more often consider JAK inhibitors in the treatment of refractory rheumatoid arthritis in current rheumatology clinics
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Favalli EG / 2014 / Methotrexate for the treatment of rheumatoid arthritis in the biologic era : still an"anchor"drug? / Autoimmun Rev 13:1102~1108
Harrington R / 2020 / JAK inhibitors in rheumatoid arthritis : an evidence-based review on the emerging clinical data / J Inflamm Res 13:519~531
Angelini J / 2020 / JAK-inhibitors for the treatment of rheumatoid arthritis : a focus on the present and an outlook on the future / Biomolecules 10:1002
Clark JD / 2014 / Discovery and development of Janus kinase(JAK)inhibitors for inflammatory disease / J Med Chem 57:5023~5038
Schindler C / 2007 / JAK-STAT signaling : from interferons to cytokines / J Biol Chem 282:20059~20063
Harrington R / 2020 / JAK inhibitors in rheumatoid arthritis : an evidence-based review on the emerging clinical data / J Inflamm Res 13:519~531
Angelini J / 2020 / JAK-inhibitors for the treatment of rheumatoid arthritis : a focus on the present and an outlook on the future / Biomolecules 10:1002
Clark JD / 2014 / Discovery and development of Janus kinase(JAK)inhibitors for inflammatory disease / J Med Chem 57:5023~5038
Schindler C / 2007 / JAK-STAT signaling : from interferons to cytokines / J Biol Chem 282:20059~20063
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