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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 195 - 195 (1page)
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Psoriasis, a chronic inflammation-mediated skin disease, affects 2-3% of the total populations in the world. It is characterized by keratinocytes hyperproliferation and immune cell infiltration. The JAK/STAT3 and JAK/STAT1 signaling pathways triggered by IL-6 and IFN- γ from dendritic cell and T lymphocytes, play important roles in psoriasis. Thus, blockade of JAK/STAT signaling will be potential strategy in psoriasis. CMX, an extract of Centipeda minima enriched in Brevilin A, Arnicolide D, Arnicolide C, and Microhelenin C which have already been reported in anti-inflammation, anti-cancer, antiallergy, and suppression of proliferation. We established chronic inflammatory and cell proliferating models in macrophages and keratinocytes with LPS (250ng/mL), rh-IL-6 (10ng/mL), or rh-IFN-γ (10ng/mL) to evaluate t ... 전체 초록 보기
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