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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 489 - 494 (6page)
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초록· 키워드
오류제보하기
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model was induced by sciatic nerve chronic compression injury (CCI) and behavior tests were performed to analyze the pain behaviors upon mechanical, thermal and cold stimulations. Spinal expression of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was detected by qRT-PCR and western blot. JAK2 was also overexpressed in procaine treated model rats for behavior tests. Results showed that procaine pretreatment improved the pain behaviors of model rats upon mechanical, thermal and cold stimulations, with the best effect occurring on the $15^{th}$ day post model construction (p<0.05). Procaine also inhibited JAK2 and STAT3 expression in both mRNA (p<0.05) and protein levels. Overexpression of JAK2 increased STAT3 level and reversed the improvement effects of procaine in pain behaviors (p<0.01). These findings indicate that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling.
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참고문헌 (30)
참고문헌 신청
Ahn, H. Y / 1988 / Inhibitory effects of procaine on contraction and calcium movement in vascular and intestinal smooth muscles / Br. J. Pharmacol 94:789~796
Backonja, M / 2010 / Backonja, M. and Woolf, C. J. (2010) Future directions in neuropathic pain therapy: closing the translational loop / Oncologist 15(Suppl 2):24~29
Campbell, J. N / 2006 / Mechanisms of neuropathic pain / Neuron 52:77~92
Datta, S / 2010 / Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli / Mol. Pain 6:7
Dominguez, E / 2010 / SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury / J. Neurosci 30:5754~5766
Backonja, M / 2010 / Backonja, M. and Woolf, C. J. (2010) Future directions in neuropathic pain therapy: closing the translational loop / Oncologist 15(Suppl 2):24~29
Campbell, J. N / 2006 / Mechanisms of neuropathic pain / Neuron 52:77~92
Datta, S / 2010 / Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli / Mol. Pain 6:7
Dominguez, E / 2010 / SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury / J. Neurosci 30:5754~5766
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