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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 135 - 140 (6page)
이용수
초록· 키워드
오류제보하기
Temperature signaling can be initiated by members of transient receptor potential (thermo-TRP) channels. Hot and cold substances applied to teeth usually elicit pain sensation. Since odontoblasts constitute a well-defined layer between the pulp and the mineralized dentin, being first to encounter thermal stimulation from oral cavity, they may be involved in sensory transduction process, in addition to their primary function as formation of dentin. We investigated whether thermo-TRP channels are expressed in a odontoblast cell line, MDPC-23. The expressions of thermo-TRP channels were examined using reverse transcription polymerase chain reaction (RT-PCR), immunohistoche-mistry, fluorometric calcium imaging. Analysis of RT-PCR revealed mRNA expression of TRPV1, TRPV2, TRPV4 and TRPM8, but no TRPV3, TRPA1. Immunohistochemical approach failed to detect TRPV1 expression. Whereas the application of 4-phorbol-12,13-didecanoate(10 M, a TRPV4 agonist), menthol(1 mM, a TRPM8 agonist) and icilin (10 M, a TRPM8 agonist) produced the enhancement of intracellular calcium concentration, capsaicin(1 M, a TRPV1 agonist) did not. Our results suggest that subfamily of thermo-TRP channels expressed in odontoblasts may serve as thermal or mechanical transducer in teeth.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
/ 1985 / Physiological properties of intradental mechanoreceptors : 389 ~ 395
/ 1988 / Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ 103 : 155 ~ 169
/ 1989 / Afferent C fibre innervation of cat tooth pulp confirmation by electrophysiological methods : 663 ~ 675
/ 1996 / The functional properties of intradental nerves:Dentin/ pulp complex : 146 ~ 153
/ 1998 / Cloned 3T6 cell line from CD-1 mouse fetal molar dental papillae 37 : 233 ~ 249
/ 1988 / Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ 103 : 155 ~ 169
/ 1989 / Afferent C fibre innervation of cat tooth pulp confirmation by electrophysiological methods : 663 ~ 675
/ 1996 / The functional properties of intradental nerves:Dentin/ pulp complex : 146 ~ 153
/ 1998 / Cloned 3T6 cell line from CD-1 mouse fetal molar dental papillae 37 : 233 ~ 249
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