지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 68 - 80 (13page)
이용수
초록· 키워드
오류제보하기
Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wild-type (TP53WT) and mutant (TP53m) OC datasets. TP53 was highly mutated in OC compared to other cancer types. Among OC subtypes, CXCL14 was predominantly expressed in clear cell OC, and CCL15 and CCL20 in mucinous OC. TP53WT endometrioid OC highly expressed CXCL14 compared to TP53m, showing better progression-free survival but no difference in overall survival (OS). TP53m serous OC highly expressed CCL8, CCL20, CXCL10 and CXCL11 compared to TP53WT. CXCL12 and CCL21 were associated with poor OS in TP53WT serous OC. CXCR2 was associated with poor OS in TP53m serous OC, while CXCL9, CCL5, CXCR4, CXCL11, and CXCL13 were associated with better OS. Taken together, specific chemokine signatures may differentially influence OS in TP53WT and TP53m OC.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
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National Cancer Institute (US). / Surveillance, Epidemiology, and End Results program. Statistical summaries: cancer stat fact sheets (ovary) and cancer statistics review (CSR), 1975-2013
National Cancer Institute / 2016 / Surveillance, Epidemiology, and End Results (SEER) program. SEER*Stat Database: NAACCR Incidence Data - CiNA Analytic File -, for Expanded Races, Custom File With County, ACS Facts and Figures projection Project (which includes data from CDC's National Program of Cancer Registries (NPCR), CCCR's Provincial and Territorial Registries, and the NCI's Surveillance, Epidemiology and End Results (SEER) Registries), certified by the North American Association of Central Cancer Registries (NAACCR) as meeting high-quality incidence data standards for the specified time periods, submitted December 2016
Rojas V / 2016 / Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment / Int J Mol Sci 17:E2113
Doubeni CA / 2016 / Diagnosis and management of ovarian cancer / Am Fam Physician 93:937~944
National Cancer Institute (US). / Surveillance, Epidemiology, and End Results program. Statistical summaries: cancer stat fact sheets (ovary) and cancer statistics review (CSR), 1975-2013
National Cancer Institute / 2016 / Surveillance, Epidemiology, and End Results (SEER) program. SEER*Stat Database: NAACCR Incidence Data - CiNA Analytic File -, for Expanded Races, Custom File With County, ACS Facts and Figures projection Project (which includes data from CDC's National Program of Cancer Registries (NPCR), CCCR's Provincial and Territorial Registries, and the NCI's Surveillance, Epidemiology and End Results (SEER) Registries), certified by the North American Association of Central Cancer Registries (NAACCR) as meeting high-quality incidence data standards for the specified time periods, submitted December 2016
Rojas V / 2016 / Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment / Int J Mol Sci 17:E2113
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UCI(KEPA) : I410-ECN-0101-2018-517-003392115