지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제1호
- 발행연도
- 2016.1
- 수록면
- 45 - 51 (7page)
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Background: A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.
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참고문헌 (33)
참고문헌 신청
Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24:147~174
Adkinson NF / 2009 / Middleton’s allergy: principles and practice / Mosby/Elsevier
Legrand F / 2010 / Human eosinophils exert TNFalpha and granzyme A-mediated tumoricidal activity toward colon carcinoma cells / J Immunol 185:7443~7451
Capron M / 2009 / Functions of eosinophil granulocytes: from anti-parasite immunity to anti-tumoral potential / Bull Acad Natl Med 193:339~346
Pretlow TP / 1983 / Eosinophil infiltration of human colonic carcinomas as a prognostic indicator / Cancer Res 43:2997~3000
Adkinson NF / 2009 / Middleton’s allergy: principles and practice / Mosby/Elsevier
Legrand F / 2010 / Human eosinophils exert TNFalpha and granzyme A-mediated tumoricidal activity toward colon carcinoma cells / J Immunol 185:7443~7451
Capron M / 2009 / Functions of eosinophil granulocytes: from anti-parasite immunity to anti-tumoral potential / Bull Acad Natl Med 193:339~346
Pretlow TP / 1983 / Eosinophil infiltration of human colonic carcinomas as a prognostic indicator / Cancer Res 43:2997~3000
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