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논문 기본 정보

자료유형
학술저널
저자정보
Kyung-Eun Lee (Chonnam National University Medical School & Hospital Gwangju Korea) Dong-Jin Park (Chonnam National University Medical School) Sung-Eun Choi (Chonnam National University Hospital Chonnam National University Medical School) Ji-Hyoun Kang (Chonnam National University Hospital Chonnam National University Medical School) Yi-Rang Yim (Chonnam National University Hospital Chonnam National University Medical School) Ji-Eun Kim (Chonnam National University Medical School) Jeong-Won Lee (Chonnam National University Hospital Chonnam National University Medical School) Lihui Wen (전남대학교) Tae-Jong Kim (Chonnam National University Hospital Chonnam National University Medical School) Yong-Wook Park (Chonnam National University Medical School) Ji Shin Lee (Chonnam National University) Kyung Chul Yoon (Chonnam National University Medical School) Shin-Seok Lee (Chonnam National University)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제23권 제5호
발행연도
2016.1
수록면
297 - 303 (7page)

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Objective. To evaluate the laboratory and clinical manifestations of Sjögren’s syndrome (SS) association with chemokine (C-X-C motif) ligand 1 (CXCL1) expression in the ductal and acinar salivary gland epithelial cells (SGEC) of the minor salivary glands. Methods. The sociodemographic data of 106 SS patients was obtained, and the glandular and extraglandular manifestations of the disease documented. The minor salivary glands were biopsied and the laboratory findings analyzed. European League Against Rheumatism SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) scores were obtained during biopsy. An immunohistochemical approach was used to define the expression of CXCL1 in the salivary glands. Results. Of 106 patients, the minor salivary glands of 22 patients (20.7%) stained positively for CXCL1. Such CXCL1-positive patients exhibited higher ESSDAI scores at the time of biopsy than the CXCL1-negative patients (3.86±2.27 vs. 2.64±1.62, p=0.015). Lymphadenopathy was more frequently observed in CXCL1-positive patients, compared with CXCL1-negative patients (31.8% vs. 9.5%, p=0.014). No differences between groups were identified in terms of sociodemographic characteristics, laboratory data, or the extent of the glandular manifestation of SS. Conclusion. The expression of CXCL1 within the ductal and acinar SGEC of SS patients is associated with lymphadenopathy and elevated clinical disease activity. CXCL1 may play an important role in the disease activity and prognosis of SS. (J Rheum Dis 2016;23:297-303)

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