지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 81 - 94 (14page)
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초록· 키워드
오류제보하기
One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells. Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating glucose and proinflammatory chemokine CXCL1 levels. Ascites in obese mice had higher levels of macrophages (Mφ) and chemokines including CCL2, CXCL12, CXCL13, G-CSF and M-CSF. Omental tumor tissues in obese mice had more adipocytes than lean mice. Our data suggest that obesity may accelerate the peritoneal dissemination of OC through higher production of pro-inflammatory chemokines and Mφ recruitment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (81)
참고문헌 신청
Arroyo-Johnson C / 2016 / Obesity epidemiology worldwide / Gastroenterol Clin North Am 45:571~579
Calle EE / 2003 / Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults / N Engl J Med 348:1625~1638
Smith KB / 2016 / Obesity statistics / Prim Care 43:121~135
Torre LA / 2018 / Ovarian cancer statistics, 2018 / CA Cancer J Clin 68:284~296
Yeung TL / 2015 / Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: cell and molecular processes in cancer metastasis / Am J Physiol Cell Physiol 309:C444~C456
Calle EE / 2003 / Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults / N Engl J Med 348:1625~1638
Smith KB / 2016 / Obesity statistics / Prim Care 43:121~135
Torre LA / 2018 / Ovarian cancer statistics, 2018 / CA Cancer J Clin 68:284~296
Yeung TL / 2015 / Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: cell and molecular processes in cancer metastasis / Am J Physiol Cell Physiol 309:C444~C456
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UCI(KEPA) : I410-ECN-0101-2019-517-000338046