지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 130 - 136 (7page)
이용수
초록· 키워드
오류제보하기
Johne"s disease (JD) is a chronic, debilitating disease of ruminants including cows, and is caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is not only important in animal husbandry, but also in public health as it is associated with the onset of Crohn"s disease, a chronic inflammatory bowel disease in humans. JD, like other mycobacterial diseases including tuberculosis, is classified into different stages based on the progression of infection. In addition, development of diagnostic assays that can distinguish between subclinical and clinical stages of JD is essential to control mycobacterial infection by providing an effective treatment. For the development of novel diagnostic methods of JD, it is important to investigate and understand the mRNA expression of the various immune markers in individuals at each stage of infection. In this study, we measured the levels of Th1-type chemokines, CXCR3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11 in MAP-infected bovine blood by interferon (IFN)-γ release assay (IGRA) using IFN-γ as an alternative biomarker. The association of mRNA expression patterns of these chemokines with the MAP infection stages was analyzed and IFN-γ, CCL5, and CXCL10 were found to be significantly upregulated compared to IFN-γ, the biomarker used in IGRA. Our results further indicate that IFN-γ levels significantly increased in individuals with MAPspecific antibody, and CCL5 and CXCL10 levels significantly increased in those with MAP DNA. In particular, CCL5 was significantly upregulated in individuals, in which both MAP-specific antibody and MAP DNA were detected, but the expression of CXCL10 was specifically elevated in MAP DNA-detected individuals without MAPspecific antibody.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (16)
참고문헌 신청
[학술지(정기간행물)] - Motiwala AS / 2006 / Comparative transcriptional analysis of human macrophages exposed to animal and human isolates of Mycobacterium avium subspecies paratuberculosis with diverse genotypes / Infect Immun 74 : 6046 ~ 6056
[학술지(정기간행물)] - Coussens PM. / 2001 / Mycobacterium paratuberculosis and the bovine immune system / Anim Health Res Rev 2 : 141 ~ 161
[학술지(정기간행물)] - Sechi LA / 2005 / Detection and isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia / Am J Gastroenterol 100 : 1529 ~ 1536
[학술지(정기간행물)] - Shin AR / 2010 / Identification of seroreactive proteins in the culture filtrate antigen of Mycobacterium avium ssp. paratuberculosis human isolates to sera from Crohn's disease patients / FEMS Immunol Med Microbiol 58 : 128 ~ 137
[학술지(정기간행물)] - Bögli-Stuber K / 2005 / Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy cattle by real-time PCR and culture: a comparison of the two assays / J Appl Microbiol 99 : 587 ~ 597
[학술지(정기간행물)] - Coussens PM. / 2001 / Mycobacterium paratuberculosis and the bovine immune system / Anim Health Res Rev 2 : 141 ~ 161
[학술지(정기간행물)] - Sechi LA / 2005 / Detection and isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia / Am J Gastroenterol 100 : 1529 ~ 1536
[학술지(정기간행물)] - Shin AR / 2010 / Identification of seroreactive proteins in the culture filtrate antigen of Mycobacterium avium ssp. paratuberculosis human isolates to sera from Crohn's disease patients / FEMS Immunol Med Microbiol 58 : 128 ~ 137
[학술지(정기간행물)] - Bögli-Stuber K / 2005 / Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy cattle by real-time PCR and culture: a comparison of the two assays / J Appl Microbiol 99 : 587 ~ 597
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UCI(KEPA) : I410-ECN-0101-2019-475-000334029