지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 3 - 14 (12page)
이용수
초록· 키워드
오류제보하기
Background: Platelet-rich plasma (PRP) stimulates cell proliferation and enhances matrix gene expression and synthesis. However, there have been no comparative study of the PRP effect on the normal and degenerative tenocytes. The purpose of this study was to compare the effect of PRP on tenocytes from normal and degenerative tendon.
Methods: Tendon tissues were obtained from patients undergoing arthroscopic repair (n=9) and from healthy donors (n=3). Tenocytes were cultured with 10% (vol/vol) platelet-poor plasma, PRP activated with calcium, and PRP activated with calcium and thrombin. The total cell number was assessed at days 7 and 14. The expressions of type I and III collagen, decorin, tenascin-C, and scleraxis were evaluated by quantitative real-time reverse transcriptase polymerase chain reaction. The total collagen and glycosaminoglycan (GAG) synthesis was evaluated at days 7 and 14.
Results: No differences were observed between the groups at day 7, but cell proliferation was remarkably increased in tenocytes from the degenerative tendon at day 14. In both tenocyte groups, the gene expressions of type I and III collagen were up-regulated. GAG synthesis was greater in the normal tendon, whereas the expressions of decorin and tenascin-C were increased in tenocytes from the degenerative tendon. Tenocytes from the degenerative tendon had higher fold-change of GAG synthesis and a lower collagen III/I ratio than normal tenocytes.
Conclusions: PRP promoted the cell proliferation and enhanced the synthesis of tendon matrix in both groups. PRP has a greater positive effect on cell proliferation, matrix gene expression and synthesis in tenocytes from degenerative tendon.
Methods: Tendon tissues were obtained from patients undergoing arthroscopic repair (n=9) and from healthy donors (n=3). Tenocytes were cultured with 10% (vol/vol) platelet-poor plasma, PRP activated with calcium, and PRP activated with calcium and thrombin. The total cell number was assessed at days 7 and 14. The expressions of type I and III collagen, decorin, tenascin-C, and scleraxis were evaluated by quantitative real-time reverse transcriptase polymerase chain reaction. The total collagen and glycosaminoglycan (GAG) synthesis was evaluated at days 7 and 14.
Results: No differences were observed between the groups at day 7, but cell proliferation was remarkably increased in tenocytes from the degenerative tendon at day 14. In both tenocyte groups, the gene expressions of type I and III collagen were up-regulated. GAG synthesis was greater in the normal tendon, whereas the expressions of decorin and tenascin-C were increased in tenocytes from the degenerative tendon. Tenocytes from the degenerative tendon had higher fold-change of GAG synthesis and a lower collagen III/I ratio than normal tenocytes.
Conclusions: PRP promoted the cell proliferation and enhanced the synthesis of tendon matrix in both groups. PRP has a greater positive effect on cell proliferation, matrix gene expression and synthesis in tenocytes from degenerative tendon.
목차
Introduction
Methods
Discussion
Conclusion
References
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Urwin M / 1998 / Estimating the burden of musculoskeletal disorders in the community: the comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation / Ann Rheum Dis 57 (11) : 649 ~ 655
[학술지(정기간행물)] - Jo CH / 2017 / Degree of tendon degeneration and stage of rotator cuff disease / Knee Surg Sports Traumatol Arthrosc 25 (7) : 2100 ~ 2108
[학술지(정기간행물)] - Matthews TJ / 2006 / Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases / J Bone Joint Surg Br 88 (4) : 489 ~ 495
[학술지(정기간행물)] - Chaudhury S / 2012 / Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies / J Shoulder Elbow Surg 21 (2) : 191 ~ 199
[학술지(정기간행물)] - Riley GP / 2005 / Gene expression and matrix turnover in overused and damaged tendons / Scand J Med Sci Sports 15 (4) : 241 ~ 251
[학술지(정기간행물)] - Jo CH / 2017 / Degree of tendon degeneration and stage of rotator cuff disease / Knee Surg Sports Traumatol Arthrosc 25 (7) : 2100 ~ 2108
[학술지(정기간행물)] - Matthews TJ / 2006 / Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases / J Bone Joint Surg Br 88 (4) : 489 ~ 495
[학술지(정기간행물)] - Chaudhury S / 2012 / Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies / J Shoulder Elbow Surg 21 (2) : 191 ~ 199
[학술지(정기간행물)] - Riley GP / 2005 / Gene expression and matrix turnover in overused and damaged tendons / Scand J Med Sci Sports 15 (4) : 241 ~ 251
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UCI(KEPA) : I410-ECN-0101-2018-514-001806019