지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 256 - 264 (9page)
- DOI
- 10.7841/ksbbj.2017.32.4.256
이용수
초록· 키워드
오류제보하기
Boehmeria nivea (L.) Gaud. has been widely cultivated in Southeast Asia area including Korea and used for disease prevention in Korea. However, safety studies have not been reported yet. In this study, we performed the single dose toxicity test, repeated dose toxicity test and bacterial reverse mutation test to evaluate the safety of 70% ethanolic extract of Boehmeria nivea (L.) Gaud. (EBN). In the single dose toxicity test, EBN was orally administered to Sprague-Dawley (SD) rats at the concentrations 0, 500, 1,000, and 2,000 mg/kg for 14 days. EBN did not cause mortality and LD50 was assessed to be over 2,000 mg/kg. Similarly, SD rats were administered at doses of 0, 500, 1,000 and 2,000 mg/kg for 14 days in the repeated dose toxicity test, and EBN also caused neither mortality, unusual signs of general behavior, nor significant changes in bodyweight, food intake, or organ weights. Some hematological parameters such as white blood cell, lymphocyte, and large unstained cell and serum biochemical estimates including total protein significantly changed but in a non-dose dependent manner. Other estimates were not significantly different between treatment and control groups. Moreover, EBN was negative in reverse mutation test using Salmonella Typhimurium (TA98, TA100, TA1535, and TA1357) and Escherichia coli (WP2uvrA) regardless of application of the metabolic activating system (S9 mix). Therefore, we suggest that EBN could be used as nontoxic material for functional food development.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (18)
참고문헌 신청
Kim, C., M. In, and D. C. Kim (2015) In vitro antioxidant activity of ethanol extract from Boehmeria nivea L. leaves. Food Eng. Prog. 19: 76-81.
Park, M., J. Lee, A. R. Kim, H. Jung, and M. Lee (2010) Physicochemical composition of ramie leaves (Boehmeria nivea L.). Korean J. Food Preserv. 17: 853-860.
Lee, Y. R., J. W. Nho, I. G. Hwang, W. J. Kim, Y. J. Lee, and H. S. Jeong (2009) Chemical composition and antioxidant activity of ramie leaf (Boehmeria nivea L.). Food Sci. Biotechnol. 18: 1096- 1099.
Kim, I., K. Park, H. Yu, and M. Shin (2009) Antioxidant activities and cell viability against cancer cells of Adenophora remotiflora leaves. J East Asian Soc Dietary Life. 19: 384-394.
Lee, J., M. Park, A. Kim, and M. Lee (2011) Effects of ramie leaves on improvement of lipid metabolism and antiobesity effect in rats fed a high fat/high cholesterol diet. Korean J. Food Sci. Technol. 43: 83-90.
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UCI(KEPA) : I410-ECN-0101-2018-470-001673582