지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 145 - 150 (6page)
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초록· 키워드
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Boehmeria nivea (L.) Gaud., a flowering plant, has been widely cultivated in Asian countries including Korea. It has been reported that B. nivea exhibits health beneficial effects for the prevention of inflammation, oxidative stress, and virusrelated diseases. In this study, we evaluated the inhibitory effect of B. nivea on adipocyte differentiation and angiogenesis. DPPH radical scavenging activities of 70% ethanol extract of B. nivea (EBN) and water extract of B. nivea (WBN) were 90.8±1.1% and 20±6.9%, respectively. EBN was also effective in the reduction of adipocyte differentiation in 3T3-L1 cells. We next examined the transcriptional activity of peroxisome proliferator-activated receptor gamma (PPAR-γ), a pivotal target for anti-obesity. We found that treatment with rosiglitazone induced the transactivation of PPAR-γ. Under the same condition, 800 μg/mL EBN reduced the transactivation of PPAR-γ in rosiglitazone-induced cells. These results demonstrate that EBN-inhibited adipocyte differentiation was accompanied by PPAR-γ inhibition. The study also tested whether EBN exhibits an anti-angiogenic effect by inhibiting tube formation in HUVECs. We found that EBN effectively inhibits tube formation, suggesting that EBN exhibited an anti-angiogenic effect. Taken together, B. nivea can be used as a functional food for the prevention of obesity and angiogenesisrelated diseases including cancer.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Frühbeck, G. / 2014 / Regulation of adipocyte lipolysis / Nutr. Res. Rev 27 : 63 ~ 93
[학술지(정기간행물)] - Lucke-Wold, B. P. / 2014 / Aging, the metabolic syndrome, and ischemic stroke: redefining the approach for studying the blood-brain barrier in a complex neurological disease / Adv. Pharmacol 71 : 411 ~ 449
[학술지(정기간행물)] - Mancini, M. C. / 2006 / Investigational therapies in the treatment of obesity / Expert Opin. Investig. Drugs 15 : 897 ~ 915
[학술지(정기간행물)] - Mantzoros, C. S. / 1996 / Activation of beta(3)adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice / Diabetes 45 : 909 ~ 914
[학술지(정기간행물)] - Wang, S. / 2014 / Novel insights of dietary polyphenols and obesity / J. Nutr. Biochem 25 : 1 ~ 18
[학술지(정기간행물)] - Lucke-Wold, B. P. / 2014 / Aging, the metabolic syndrome, and ischemic stroke: redefining the approach for studying the blood-brain barrier in a complex neurological disease / Adv. Pharmacol 71 : 411 ~ 449
[학술지(정기간행물)] - Mancini, M. C. / 2006 / Investigational therapies in the treatment of obesity / Expert Opin. Investig. Drugs 15 : 897 ~ 915
[학술지(정기간행물)] - Mantzoros, C. S. / 1996 / Activation of beta(3)adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice / Diabetes 45 : 909 ~ 914
[학술지(정기간행물)] - Wang, S. / 2014 / Novel insights of dietary polyphenols and obesity / J. Nutr. Biochem 25 : 1 ~ 18
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UCI(KEPA) : I410-ECN-0101-2017-470-001334568