지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 260 - 267 (8page)
이용수
초록· 키워드
오류제보하기
CD99 signaling is crucial to a diverse range of biological functions including survival and proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity through mitogen-activated protein (MAP) kinase pathways in a T-lymphoblastic lymphoma cell line Jurkat and in breast cancer cell lines. In this study, we report that CD99 differentially regulated AP-1 activity in the human myeloma cell line RPMI8226. CD99 was highly expressed and the CD99 engagement led to activation of the MAP kinases, but suppressed AP-1 activity by inducing the expression of basic leucine zipper transcription factor, ATF-like (BATF), a negative regulator of AP-1 in RPMI8226 cells. By contrast, engagement of CD99 enhanced AP-1 activity and did not change the BATF expression in Jurkat cells. CD99 engagement reduced the proliferation of RPMI8226 cells and expression of cyclin 1 and 3. Overall, these results suggest novel CD99 functions in RPMI8226 cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Levy, R. / 1979 / A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies / Proc. Natl. Acad. Sci. U.S.A 76 : 6552 ~ 6556
[학술지(정기간행물)] - Dworzak, M. N. / 1994 / Flow cytometric assessment of human MIC2 expression in bone marrow, thymus, peripheral blood / Blood 83 : 415 ~ 425
[학술지(정기간행물)] - Park, C. K. / 1999 / High CD99 expression in memory T B cells in reactive lymph nodes / J. Korean Med. Sci 14 : 600 ~ 606
[학술지(정기간행물)] - Bernard, G. / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4＋ CD8＋ thymocytes / J. Immunol 154 : 26 ~ 32
[학술지(정기간행물)] - Hahn, J. H. / 1997 / CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes, its gene encodes both positive negative regulators of cellular adhesion / J. Immunol 159 : 2250 ~ 2258
[학술지(정기간행물)] - Dworzak, M. N. / 1994 / Flow cytometric assessment of human MIC2 expression in bone marrow, thymus, peripheral blood / Blood 83 : 415 ~ 425
[학술지(정기간행물)] - Park, C. K. / 1999 / High CD99 expression in memory T B cells in reactive lymph nodes / J. Korean Med. Sci 14 : 600 ~ 606
[학술지(정기간행물)] - Bernard, G. / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4＋ CD8＋ thymocytes / J. Immunol 154 : 26 ~ 32
[학술지(정기간행물)] - Hahn, J. H. / 1997 / CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes, its gene encodes both positive negative regulators of cellular adhesion / J. Immunol 159 : 2250 ~ 2258
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UCI(KEPA) : I410-ECN-0101-2016-511-002009704