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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제2호
- 발행연도
- 2016.1
- 수록면
- 96 - 103 (8page)
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Background: Immunohistochemical demonstration of CD20 in diffuse large B-cell lymphoma (DLBCL) is prerequisite not only for the diagnosis but also for assigning patients to rituximabcontaining chemotherapy. However, little is known about the impact of abundance of CD20 expression assessed by immunohistochemistry on the clinical outcome of DLBCL. We performed a semi-quantitative immunohistochemical analysis of CD20 expression in DLBCL to examine the prognostic implication of the level of CD20 expression. Methods: Pre-treatment diagnostic tissue samples from 48 DLBCL patients who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen were represented in a tissue microarray and immunostained for CD20. The relative abundance of CD20 expression was semi-quantitatively scored using a web-based ImmunoMembrane plug-in. Receiver operating characteristic curve analysis was used to determine a prognostically relevant cut-off score in order to dichotomize the patients into CD20-high versus CD20-low groups. Results: The levels of CD20 expression were heterogeneous among the patients, with a wide and linear distribution of scores. Patients in CD20-low group showed significantly poor clinical outcome. Conclusions: The levels of CD20 expression in DLBCL are heterogeneous among the patients with DLBCL. A subgroup of the patients with CD20 expression levels below the cut-off score showed poor clinical outcome.
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참고문헌 (22)
참고문헌 신청
Stein H / 2008 / WHO classification of tumours of haematopoietic and lymphoid tissues / IARC Press :233~237
Coiffier B / 2005 / State-of-the-art therapeutics: diffuse large B-cell lymphoma / J Clin Oncol 23:6387~6393
Boross P / 2012 / Mechanisms of action of CD20 antibodies / Am J Cancer Res 2:676~690
김규호 / 2013 / In-house Manual Construction of High-Density and High-Quality Tissue Microarrays by Using Homemade Recipient Agarose-Paraffin Blocks / Journal of Pathology and Translational Medicine 47(3):238~244
Berglund M / 2005 / Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis / Mod Pathol 18:1113~1120
Coiffier B / 2005 / State-of-the-art therapeutics: diffuse large B-cell lymphoma / J Clin Oncol 23:6387~6393
Boross P / 2012 / Mechanisms of action of CD20 antibodies / Am J Cancer Res 2:676~690
김규호 / 2013 / In-house Manual Construction of High-Density and High-Quality Tissue Microarrays by Using Homemade Recipient Agarose-Paraffin Blocks / Journal of Pathology and Translational Medicine 47(3):238~244
Berglund M / 2005 / Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis / Mod Pathol 18:1113~1120
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