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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 305 - 312 (8page)
- DOI
- 10.15188/kjopp.2015.08.29.4.305
이용수
초록· 키워드
오류제보하기
Paeonol is a major component found in the Paeoniaceae family such as Paeonia suffruticosa Andrews. Paeonia suffruticosa Andrews has traditionally been used to enhance blood flow and relieve joint pain in east Asian countries including China, Korea and Japan. Current research has shown that paeonol blocked the voltage-gated sodium channel and L-type calcium channel. However, there is a lack of research to reveal the relation between cardiac function and blockade of ion channels by paeonol. Therefore, the aim of this study is to investigate whether paeonol has anti-arrhythmic effects via modulating cardiac ion channels. It is collected that the effects of paeonol on multiple ion channels such as the fast sodium channel and L-type calcium channel from published papers. To incorporate the information on multi-channel block, we computed the effects using the mathematical cardiac model of the guinea-pig and rat ventricular cells (Noble 1998 and 1991 model) and induced early after-depolarizations (EADs) to generate an arrhythmia in the whole heart. Paeonol slightly shortened the action potential duration in the normal cardiac ventricular action potential by the inhibition of sodium channel and L-type calcium channel. Paeonol presented the protective effect from EADs by the inactivation of sodium channel but not L-type calcium channel. Paeonol did not show any changes when it treated on normal ventricular cells through the inhibition of sodium channel, but the protective effect of paeonol through sodium channel on EADs was dose-dependent. These findings suggest that paeonol and its original plant may possess anti-arrhythmic activity, which implies their cardioprotective effects.
목차
서론
재료 및 방법
결과
고찰
결론
Reference
참고문헌 (39)
참고문헌 신청
[인터넷자원] - Health Insurance Review and Assessment Service / / Health Insurance Statistics Annual Reports 2012, 2013, 2014
[학술지(정기간행물)] - On, Y. K / 2010 / Catheter Ablation for Tachycardia-Bradycardia Syndrome / J Card Arrhythmia 11 (3) : 23 ~ 28
[학술지(정기간행물)] - Lee, M. Y / 2010 / Sudden Cardiac Death and Prevention / J Card Arrhythmia 11 (2) : 17 ~ 23
[학술지(정기간행물)] - Lee, J. E. / 2014 / Early Repolarization Syndrome with Idiopathic Ventricular Fibrillation / Ewha Med J 37 : 112 ~ 115
[학술지(정기간행물)] - Bard, J. / 2013 / Plenary Discussion of the Conceptual Foundations of Systems Biology / Prog Biophys Mol Biol 111 : 137 ~ 140
[학술지(정기간행물)] - On, Y. K / 2010 / Catheter Ablation for Tachycardia-Bradycardia Syndrome / J Card Arrhythmia 11 (3) : 23 ~ 28
[학술지(정기간행물)] - Lee, M. Y / 2010 / Sudden Cardiac Death and Prevention / J Card Arrhythmia 11 (2) : 17 ~ 23
[학술지(정기간행물)] - Lee, J. E. / 2014 / Early Repolarization Syndrome with Idiopathic Ventricular Fibrillation / Ewha Med J 37 : 112 ~ 115
[학술지(정기간행물)] - Bard, J. / 2013 / Plenary Discussion of the Conceptual Foundations of Systems Biology / Prog Biophys Mol Biol 111 : 137 ~ 140
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