지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 536 - 542 (7page)
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초록· 키워드
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Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.
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참고문헌 (39)
참고문헌 신청
Ayo, S. H. / 1990 / High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells / Am. J. Pathol 136:1339~1348
Azadbakht, L. / 2009 / Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial / J. Ren. Nutr 19:479~486
Azadbakht, L. / 2008 / Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial / Diabetes Care 31:648~654
Chan, K. / 2004 / Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction / Life Sci 75:3157~3171
Dai, M. / 2000 / Inhibitory effect of paeonol on lipid peroxidational reaction and oxidational decorate of low density lipoprotein / Zhongguo Zhong Yao Za Zhi 25:625~627
Azadbakht, L. / 2009 / Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial / J. Ren. Nutr 19:479~486
Azadbakht, L. / 2008 / Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial / Diabetes Care 31:648~654
Chan, K. / 2004 / Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction / Life Sci 75:3157~3171
Dai, M. / 2000 / Inhibitory effect of paeonol on lipid peroxidational reaction and oxidational decorate of low density lipoprotein / Zhongguo Zhong Yao Za Zhi 25:625~627
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