지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.21 No.4
- 발행연도
- 2015.1
- 수록면
- 494 - 502 (9page)
이용수
초록· 키워드
오류제보하기
Gastrointestinal (GI) dysmotility is a severe, and common complication in patients with spinal cord injury (SCI). Current therapeutic methods using acetylcholine analogs or laxative agents have unwanted side effects, besides often fail to have desired effect. Various ion channels such as ATP-sensitive potassium (KATP) channel, calcium ions (Ca2+)-activated potassium ions (K+) channels, voltage-sensitive Ca2+ channels and chloride ion (Cl?) channels are abundantly expressed in GI tissues, and play an important role in regulating GI motility. The release of neurotransmitters from the enteric nerve terminal, innervating GI interstitial cells of Cajal (ICC), and smooth muscle cells (SMC), causes inactivation of K+ and Cl? channels, increasing Ca2+ influx into cytoplasm, resulting in membrane depolarization and smooth muscle contraction. Thus, agents directly regulating ion channels activity either in ICC or in SMC may affect GI peristalsis and would be potential therapeutic target for the treatment of GI dysmotility with SCI.
목차
등록된 정보가 없습니다.
참고문헌 (61)
참고문헌 신청
Chung EA / 2006 / Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury / Prog Brain Res 152:317~333
Bauman WA / 2002 / Heiner sell lectureship: secondary medical consequences of spinal cord injury / Top Spinal Cord Inj Rehabil 18:354~378
Coulson FR / 2003 / Muscarinic acetylcholine receptors and airway diseases / Pharmacol Ther 98:59~69
Rajendran SK / 1992 / Gastrointestinal transit after spinal cord injury: effect of cisapride / Am J Gastroenterol 87:1614~1617
Somlyo AP / 2003 / Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase / Physiol Rev 83:1325~1358
Bauman WA / 2002 / Heiner sell lectureship: secondary medical consequences of spinal cord injury / Top Spinal Cord Inj Rehabil 18:354~378
Coulson FR / 2003 / Muscarinic acetylcholine receptors and airway diseases / Pharmacol Ther 98:59~69
Rajendran SK / 1992 / Gastrointestinal transit after spinal cord injury: effect of cisapride / Am J Gastroenterol 87:1614~1617
Somlyo AP / 2003 / Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase / Physiol Rev 83:1325~1358
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
GI emergency for non-GI surgeons
대한임상종양학회 학술대회지
2022 .02
-
Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks
Journal of Neurogastroenterology and Motility (JNM)
2023 .04
-
Age-dependent expression of ion channel genes in rat
The Korean Journal of Physiology & Pharmacology
2023 .01
-
GI surgical approach
대한외과학회 학술대회 초록집
2016 .11
-
Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles
Journal of Neurogastroenterology and Motility (JNM)
2016 .01
-
Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System
Journal of Neurogastroenterology and Motility (JNM)
2016 .01
-
Transcriptomic insight into the ion channel genes across tissue types and developmental stages
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons
The Korean Journal of Physiology & Pharmacology
2017 .03
-
Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Journal of Ginseng Research
2015 .10
-
[S16-2] Effects of vagotomy on GI motility and evaluation as an animal model
한국실험동물학회 학술발표대회 논문집
2024 .07
-
Challenges in Laparoscopic GI Surgery
대한임상종양학회 학술대회지
2015 .02
-
GI Function in Critically-Ill Patients
대한외과학회 학술대회 초록집
2019 .10
-
Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract
Gut and Liver
2020 .01
-
Electrophysiological Properties of Ion Channels in Ascaris suum Tissue Incorporated into Planar Lipid Bilayers
Parasites, Hosts and Diseases
2021 .08
-
Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
Journal of Neurogastroenterology and Motility (JNM)
2018 .01
-
Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix
Journal of Neurogastroenterology and Motility (JNM)
2021 .01
-
『傷寒論』 病症과 衛氣의 관계에 대한 硏究
대한한의학원전학회지
2016 .01
-
Is Interstitial Cells of Cajal?opathy Present in Gastroparesis?
Journal of Neurogastroenterology and Motility (JNM)
2015 .01
-
Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
The Korean Journal of Physiology & Pharmacology
2015 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0