지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제5호
- 발행연도
- 2020.1
- 수록면
- 373 - 384 (12page)
이용수
초록· 키워드
오류제보하기
Paeonol, quercetin, ?-sitosterol, and gallic acid extracted from Moutan Cortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumor activities. This work aimed to illustrate the potential anti-oxidative mechanism of monomers in human liver hepatocellular carcinoma (HepG2) cells-induced by hydrogen peroxide (H2O2) and to evaluate whether the hepatoprotective effect of monomers was independence or synergy in mice stimulated by carbon tetrachloride (CCl4). Monomers protected against oxidative stress in HepG2 cells in a doseresponse manner by inhibiting the generation of reactive oxygen species, increasing total antioxidant capacity, catalase and superoxide dismutase (SOD) activities, and activating the antioxidative pathway of nuclear factor E2-related factor 2/Kelchlike ECH-associated protein 1 (Nrf2/Keap1) signaling pathway. We found that the in vitro antioxidant capacities of paeonol and quercetin were better than those of ?-sitosterol and gallic acid. Furthermore, paeonol apparently diminished the levels of alanine transaminase and aspartate aminotransferase, augmented the contents of glutathione and SOD, promoted the expressions of Nrf2 and heme oxygenase-1 proteins in mice stimulated by CCl4. In HepG2 cells, paeonol, quercetin, ?-sitosterol, and gallic acid play a defensive role against H2O2-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties. Totally, paeonol and quercetin exerted anti-oxidative and hepatoprotective effects, which is independent rather than synergy.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Yu BP / 1994 / Cellular defenses against damage from reactive oxygen species / Physiol Rev 74:139~162
Berndt C / 2014 / Redox regulation by glutathione needs enzymes / Front Pharmacol 5:168
Wang P / 2017 / Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stressinduced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway / Food Chem Toxicol 102:129~142
Zitka O / 2012 / Redox status expressed as GSH : GSSG ratio as a marker for oxidative stress in paediatric tumour patients / Oncol Lett 4:1247~1253
Lin TA / 2019 / Red quinoa bran extracts protects against carbon tetrachloride-induced liver injury and fibrosis in mice via activation of antioxidative enzyme systems and blocking TGF-β1 pathway / Nutrients 11:395
Berndt C / 2014 / Redox regulation by glutathione needs enzymes / Front Pharmacol 5:168
Wang P / 2017 / Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stressinduced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway / Food Chem Toxicol 102:129~142
Zitka O / 2012 / Redox status expressed as GSH : GSSG ratio as a marker for oxidative stress in paediatric tumour patients / Oncol Lett 4:1247~1253
Lin TA / 2019 / Red quinoa bran extracts protects against carbon tetrachloride-induced liver injury and fibrosis in mice via activation of antioxidative enzyme systems and blocking TGF-β1 pathway / Nutrients 11:395
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The regulation of p62-Nrf2-Keap1 axis in dysregulation of lipid metabolism
대한동의병리학회 학술대회논문집
2015 .10
-
Paeonol의 잠재적인 항부정맥 효과의 컴퓨터 시뮬레이션 연구
동의생리병리학회지
2015 .08
-
Paeonol의 잠재적인 항부정맥 효과의 컴퓨터 시뮬레이션 연구
동의생리병리학회지
2015 .01
-
Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2023 .06
-
포제에 따른 목단피의 성분 중 (+)-Catechin, Paeoniflorin 및 Paeonol의 함량분석
생약학회지(Korean Journal of Pharmacognosy)
2016 .09
-
Sestrin2 Activates Nrf2 by Promoting p62-dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Oxidative and carbonyl stress-induced age-related macular degeneration and anti-AMD effect of codonopsis lanceolata
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Celecoxib의 항산화 작용에 따른 성체 치주인대 줄기세포 사멸억제
대한통합의학회지
2023 .05
-
Oxidative Stress, Nrf2, and Epigenetic Modification Contribute to Anticancer Drug Resistance
Toxicological Research
2017 .01
-
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Kidney Research and Clinical Practice
2021 .01
-
Nuclear factor erythroid 2-related factor 2 활성화를 통한 해간전(解肝煎)의 간세포 보호 효능 및 분자기전을 활용한 해간전(解肝煎) 구성 약물의 최적화 연구
대한한의학방제학회지
2018 .01
-
Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/β-Catenin Signaling Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Paeonol에 의한 표피줄기세포 활성화
대한화장품학회지
2016 .01
-
Investigation of Anti-inflammatory and Anti-oxidative Activities of Lonicerae Flos, Citri Pericarpium and Violae Herba Complex (LCVC)
대한한의학회지
2022 .12
-
Can antioxidants be effective therapeutics for type 2 diabetes?
Journal of Yeungnam Medical Science
2021 .01
-
Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats
Journal of Ginseng Research
2017 .07
-
？角刺 추출물의 Nrf2 활성화를 통한 간세포 보호 효과
대한본초학회지(본초분과학회지)
2015 .01
-
Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0