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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 277 - 289 (13page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.277
이용수
초록· 키워드
오류제보하기
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central nervous system (CNS). In this study, we explored the relationship between calcium channels and apoptosis or autophagy in the hippocampus of C57BL/6 mice after RF-EMF exposure with a specific absorption rate (SAR) of 4.0 W/kg for 4 weeks. Firstly, the expression level of voltage-gated calcium channels (VGCCs), a key regulator of the entry of calcium ions into the cell, was confirmed by immunoblots. We investigated and confirmed that pan-calcium channel expression in hippocampal neurons were significantly decreased after exposure to RF-EMF. With the observed accumulation of autolysosomes in hippocampal neurons via TEM, the expressions of autophagy-related genes and proteins (e.g., LC3B-II) had significantly increased. However, downregulation of the apoptotic pathway may contribute to the decrease in calcium channel expression, and thus lower levels of calcium in hippocampal neurons. These results suggested that exposure of RF-EMF could alter intracellular calcium homeostasis by decreasing calcium channel expression in the hippocampus; presumably by activating the autophagy pathway, while inhibiting apoptotic regulation as an adaptation process for 835 MHz RF-EMF exposure.
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참고문헌 (54)
참고문헌 신청
Baan R / 2011 / Carcinogenicity of radiofrequency electromagnetic fields / Lancet Oncol 12:624~626
Aldad TS / 2012 / Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice / Sci Rep 2:312
Hao D / 2013 / Effects of long-term electromagnetic field exposure on spatial learning and memory in rats / Neurol Sci 34:157~164
Chen C / 2014 / Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells / Sci Rep 4:5103
Tang J / 2015 / Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats / Brain Res 1601:92~101
Aldad TS / 2012 / Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice / Sci Rep 2:312
Hao D / 2013 / Effects of long-term electromagnetic field exposure on spatial learning and memory in rats / Neurol Sci 34:157~164
Chen C / 2014 / Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells / Sci Rep 4:5103
Tang J / 2015 / Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats / Brain Res 1601:92~101
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