지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The purpose of this study was to examine the efficacy of Picrorrhizae Rhizoma (PR) aqueous extracts on the formalin-induced paw chronic inflammation in mice.
Methods: PR extracts (500, 250 and 125mg/kg) or distilled water (DW) were orally administered once a day for 10 days to formalin-injected chronic inflammatory mice. The paw thicknesses and volumes were measured daily and the paw wet-weight and histological profiles were conducted at termination with paw tumor necrosis factor (TNF)-α contents measurement. The anti-inflammatory effects of PR extracts were compared with dexamethasone.
Results: In DW treated control group, the paw thickness, paw wet-weights and paw TNF-α contents were markedly increased. Severe chronic inflammation signs such as severe fibrosis, the formation of necrotic debris, and infiltration of inflammatory cells were detected in histopathological observations. However, these formalin-induced changes were dramatically decreased by treatment of dexamethasone and all three different dosages of PR extracts. The anti-inflammatory effects of PR at highest dose were slighter than that of dexamethasone, but it did not show any harmful effects on the body weight contrary to dexamethasone.
Conclusion: These results suggest that PR extracts have safe and favorable effects on formalin-induced chronic inflammation.
Methods: PR extracts (500, 250 and 125mg/kg) or distilled water (DW) were orally administered once a day for 10 days to formalin-injected chronic inflammatory mice. The paw thicknesses and volumes were measured daily and the paw wet-weight and histological profiles were conducted at termination with paw tumor necrosis factor (TNF)-α contents measurement. The anti-inflammatory effects of PR extracts were compared with dexamethasone.
Results: In DW treated control group, the paw thickness, paw wet-weights and paw TNF-α contents were markedly increased. Severe chronic inflammation signs such as severe fibrosis, the formation of necrotic debris, and infiltration of inflammatory cells were detected in histopathological observations. However, these formalin-induced changes were dramatically decreased by treatment of dexamethasone and all three different dosages of PR extracts. The anti-inflammatory effects of PR at highest dose were slighter than that of dexamethasone, but it did not show any harmful effects on the body weight contrary to dexamethasone.
Conclusion: These results suggest that PR extracts have safe and favorable effects on formalin-induced chronic inflammation.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Habashy RR / 2005 / Anti-inflammatory effects of jojoba liquid wax in experimental models / Pharmacol Res 51 : 95 ~ 105
2. [학술지(정기간행물)] - KIM, HYEONG-DONG / 2006 / Effect of Exopolymers from Aureobasidium pullulans on Formalin-Induced Chronic Paw Inflammation in Mice / Journal of Microbiology and Biotechnology 16 (12) : 1954 ~ 1960
3. [학술지(정기간행물)] - Hyeong-Dong Kim / 2007 / Effects of β-Glucan from Aureobasidium pullulans on Acute Inflammation in Mice / Archives of Pharmacal Research 30 (3) : 323 ~ 328
4. [학술지(정기간행물)] - Hosseinzadeh H / 2002 / Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice / BMC Pharmacol 2 : 7 ~ 12
5. [학술지(정기간행물)] - Pillai AD / 2003 / Novel drug designing approach for dual inhibitors as anti-inflammatory agents : implication of pyridine template / BiochemBiophys Res Commun 301 : 183 ~ 186
2. [학술지(정기간행물)] - KIM, HYEONG-DONG / 2006 / Effect of Exopolymers from Aureobasidium pullulans on Formalin-Induced Chronic Paw Inflammation in Mice / Journal of Microbiology and Biotechnology 16 (12) : 1954 ~ 1960
3. [학술지(정기간행물)] - Hyeong-Dong Kim / 2007 / Effects of β-Glucan from Aureobasidium pullulans on Acute Inflammation in Mice / Archives of Pharmacal Research 30 (3) : 323 ~ 328
4. [학술지(정기간행물)] - Hosseinzadeh H / 2002 / Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice / BMC Pharmacol 2 : 7 ~ 12
5. [학술지(정기간행물)] - Pillai AD / 2003 / Novel drug designing approach for dual inhibitors as anti-inflammatory agents : implication of pyridine template / BiochemBiophys Res Commun 301 : 183 ~ 186
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UCI(KEPA) : I410-ECN-0101-2016-519-001635100