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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 676 - 685 (10page)
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초록· 키워드
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Objectives: The aim of this study was to estimate the single oral toxicity of Peucedani Radix (PR) ethanol extracts. PR is one of the important herbs for removal of phlegm, the viscous turbid pathological product that can accumulate in the body and cause a variety of diseases. However, research on the pharmacologic toxicity of PR is lacking. Methods: In this study, PR was orally administered to 5-week-old male ICR mice at an oral dose of 2,000, 3,000, or 5,000 mg/kg. After a single-dose administration, the mortality and behavioral changes were observed daily and body weights were measured every two days. After 14 days, the organ weight, organ index, macroscopy, hematological analysis, and serum biochemistry analysis were determined. Results: No mortality, body weight changes, abnormal behavioral changes, or anatomical signs of toxicity were found. The organ weight, organ index, hematological analysis, and serum biochemistry analysis were also within the normal ranges. Conclusions: These results suggest that the 50% lethal dose of PR is more than 5,000 mg/kg. This could indicate that PR is a safe drug without acute toxicity and side effects.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Atanasov AG / 2015 / Discovery and resupply of pharmacologically active plant-derived natural products: A review / Biotechnol Adv 33(8):1582~1614
Newman DJ / 2016 / Natural Products as Sources of New Drugs from 1981 to 2014 / J Nat Prod 79(3):629~661
배지영 / 2010 / 전호의 생약학적 연구 / 생약학회지 41(3):157~160
Kim HK / 2014 / Korean Medicinal materials :290~291
Seo BI / 2004 / Korean Medicinal Herb / Yeong-Rim Publishing Co., Ltd :650~652
Newman DJ / 2016 / Natural Products as Sources of New Drugs from 1981 to 2014 / J Nat Prod 79(3):629~661
배지영 / 2010 / 전호의 생약학적 연구 / 생약학회지 41(3):157~160
Kim HK / 2014 / Korean Medicinal materials :290~291
Seo BI / 2004 / Korean Medicinal Herb / Yeong-Rim Publishing Co., Ltd :650~652
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