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자료유형
학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제17권 제1호
발행연도
1987.6
수록면
7 - 14 (8page)

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This experiment investigated 5 classes of immunoglobulins to Hantaan virus in patients of Hemorrhagic fever with renal syndrome from immediately after onset of the disease to 2 months. The results obtained from this experiment were as follows: 1. The highest titer of IgG antibody to Hantaan virus could be demonstrated and reached to a peak between 2nd and 3rd week from onset of fever. Most of the patients showed high titers of immunofluorescent antibody between 4,096 and 16,384. 2. IgA antibody to Hantaan virus in patients of Hemorrhagic fever with renal syndrome was relatively high and reached a peak between 2nd and 3rd week from onset of the disease, and it was maintained with high titer of antibody for 2 months. Peak titers of immunofluorescent antibody were between 1,024 and 4,096. 3. IgM antibody to Hantaan virus in the patients of Hemmorrhagic fever with renal syndrome was demonstrated in all of the patients after onset of the disease and the titers of the antibody were between 256 and 4,096 for 2 months. 4. Though IgD antibody in patients of Hemorrhagic fever with renal syndrome was reached to a peak between 2nd and 3rd weeks after onset of the disease, the titers of the antibody were within 1,024 and it was demonstrated for 2 months. 5. IgE antibody in the patients of Hemorrhagic fever with renal syndrome was irregularly appeared and the increase of antibody was demonstrated in half of the patients. Above results revealed that the demonstration of IgM could be the important criteria in diagnosis of the primary infection with Hantaan virus and that the significance of increase of IgD antibodies to Hantaan virus dur- ing illness remains to be analysed.

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