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학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제17권 제1호
발행연도
1987.6
수록면
31 - 37 (7page)

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Five patients with Hemorrhagic fever with renal syndrome who were infected with Hantaan virus were bled at one week interval for two months after illness and the sera were used for current study. Serum antibody titers against Hantaan, Seoul and Puumala viruses were tested and compared by indirect immunofluorescent antibody (IFA) technique. The results are as follows. 1. Immunofluorescent (IF) antibodies against Hantaan virus were maximal about 2-3 weeks after the onset of illness and peak reciprocal IF antibody titers were 1,024-16,384. The titers of IF antibody against Seoul virus were lower in two folds than those of Hantaan virus. 2. IF antibodies against Puumala virus were remarkablely lower. Peak IF antibody titers were attained about 2-3 weeks following the onset of illness and the reciprocal titer was 128 at the time. 3. IgM antibodies in the sera of patients were only detectable against Hantaan and Seoul viruses with same titers. Peak IF IgM antibody titers were attained about one week following the onset of illness and then decreased rapidly after three weeks. This study concluded that infections with Hantaan and Seoul viruses were not differentiated by the demonstration of IgG antibody titers but infection with Puumala virus was easily differentiated. Also, the demonstration of IgM antibody was the clue of recent infection of Hantaan or Seoul virus.

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