지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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We investigated the effects of 835-MHz electromagnetic field (EMF), one of the most popular communication frequency band in Korean code-division multiple-access (CDMA) mobile phone system, on cellular signal transduction. For this, we examined the change of intracellular calcium ([Ca<sup>2+</sup>]<sub>i</sub>), reactive oxygen species (ROS) and F-actin polymerization after exposure to 835-MHz EMF followed by the treatment of agonists in Rat-2 fibroblast cells. Culture cells were pretreated with serum-free medium and concomitantly exposed to 835-MHz at specific absorption rate (SAR) of 4.0 W/kg for 24 hr in a specialized designed apparatus based on Transverse Electro Magnetics (TEM) wave theory. Intracellular Ca<sup>2+</sup>responses to lysophosphatidic acid (LPA) and epidermal growth factor (EGF) in Rat-2 fibroblast after exposure to 835-MHz EMF were shown to be similar pattern as observed in normal cultured cells. However, the LPA-induced calcium spiking was slightly delayed to 7 sec and sustained thereafter to a little higher ground level under 835-MHz EMF radiation compared to unexposed cells. ROS production level by LPA in the exposed cells was not different from that in control. Furthermore, LPA induced the production of stress fibers with no significant difference in the exposed and unexposed cells. These results suggest that mobile phone radiation (835-MHz, SAR 4.0 W/kg) may not be directly related to signal transduction in Rat-2 fibroblasts except the slight effect of calcium spiking in LPA-induced cells but remain to be further elucidated for possible indirect intervention.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - G,Carpenter / 1999 / Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways / J Cell Biol. 146 : 697 ~ 702
[학술지(정기간행물)] - SK,Chang / 2005 / Genotoxicity evaluation of electromagnetic fields generated by 835-MHz mobile phone frequency band / Eur J Cancer Prev 14 : 175 ~ 179
[학술지(정기간행물)] - MR,Cho / 1999 / Transmembrane calcium influx induced by ac electric fields / FASEB J. 13 : 677 ~ 683
[학술지(정기간행물)] - 최종순 / 2004 / Effects of 835-MHz Radiofrequency Radiation on the Chromosomal DNA of Mouse Thymic Lymphoma L5178Y Tk+/- Cells / 환경생물 22 (4) : 507 ~ 512
[학술지(정기간행물)] - CG,Cranfield / 2001 / Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells) / Int J Radiat Biol. 77 : 1207 ~ 1217
[학술지(정기간행물)] - SK,Chang / 2005 / Genotoxicity evaluation of electromagnetic fields generated by 835-MHz mobile phone frequency band / Eur J Cancer Prev 14 : 175 ~ 179
[학술지(정기간행물)] - MR,Cho / 1999 / Transmembrane calcium influx induced by ac electric fields / FASEB J. 13 : 677 ~ 683
[학술지(정기간행물)] - 최종순 / 2004 / Effects of 835-MHz Radiofrequency Radiation on the Chromosomal DNA of Mouse Thymic Lymphoma L5178Y Tk+/- Cells / 환경생물 22 (4) : 507 ~ 512
[학술지(정기간행물)] - CG,Cranfield / 2001 / Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells) / Int J Radiat Biol. 77 : 1207 ~ 1217
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UCI(KEPA) : I410-ECN-0101-2009-510-017357000