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논문 기본 정보
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- 학술저널
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- 2015.1
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Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named $LPA_1-LPA_6$. These receptors initiate signaling cascades relevant to development, maintenance, and healing processes throughout the body. The diversity and specificity of LPA signaling, especially in relation to cancer and autoimmune disorders, makes LPA receptor modulation an attractive target for drug development. Several LPAR-specific analogues and small molecules have been synthesized and are efficacious in attenuating pathology in disease models. To date, at least three compounds have passed phase I and phase II clinical trials for idiopathic pulmonary fibrosis and systemic sclerosis. This review focuses on the promising therapeutic directions emerging in LPA signaling toward ameliorating several diseases, including cancer, fibrosis, arthritis, hydrocephalus, and traumatic injury.
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참고문헌 (100)
참고문헌 신청
An, S. / 1998 / Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid / J. Biol. Chem 273:7906~7910
Azeem, Z. / 2008 / Novel mutations in G proteincoupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3) / Hum. Genet 123:515~519
Bachner, D. / 1999 / Developmental expression analysis of murine autotaxin (ATX) / Mech. Dev 84:121~125
Bai, C. Q. / 2014 / Diagnostic and prognostic significance of lysophosphatidic acid in malignant pleural effusions / J. Thorac. Dis 6:483~490
Bandoh, K. / 1999 / Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid / J. Biol. Chem 274:27776~27785
Azeem, Z. / 2008 / Novel mutations in G proteincoupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3) / Hum. Genet 123:515~519
Bachner, D. / 1999 / Developmental expression analysis of murine autotaxin (ATX) / Mech. Dev 84:121~125
Bai, C. Q. / 2014 / Diagnostic and prognostic significance of lysophosphatidic acid in malignant pleural effusions / J. Thorac. Dis 6:483~490
Bandoh, K. / 1999 / Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid / J. Biol. Chem 274:27776~27785
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