지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Bangpungtongsung-san (BTS) is a traditional prescription that has been used for inflammation and bronchial diseases. Coronavirus disease in 2019 (COVID-19), which occurs due to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a respiratory inflammatory disease, and mast cells are one of the key cells involved in the cytokine storm. In this study, we aimed to investigate the regulatory effects and mechanisms of BTS and its active compound, α-pinene, on coronavirus infections and inflammatory responses. BTS and α-pinene decreased the expression of not only angiotensin-converting enzyme 2 (ACE2) but also transmembrane protease/serine subfamily member 2 (TMPRSS2) in stimulated human mast cell line, HMC-1 cells. Additionally, BTS and α-pinene significantly suppressed the release of key inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, thymic stromal lymphopoietin, and tumor necrosis factor-α, without compromising cell viability. Furthermore, BTS and α-pinene decreased the expression of transcription factors c-Fos and c-Jun in activated HMC-1 cells. In conclusion, the results of the study indicated that BTS inhibited the c-Jun/c-Fos signaling pathway, leading to a decrease in the levels of ACE2, TMPRSS2, and inflammatory cytokines. This suggests that BTS may be an effective agent in mitigating the cytokine storm induced by SARS-CoV-2 infection.
목차
ABSTRACT
INTRODUCTION
MATERIALS & METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
코로나바이러스19 감염증과 안지오텐신전환효소2
대한내과학회지
2020 .08
-
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19
Annals of Laboratory Medicine
2021 .01
-
코로나바이러스감염증-19 환자의 구강증상과 병리학적 기전
임상이비인후과
2021 .12
-
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
Immune Network
2021 .02
-
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective
International Neurourology Journal
2015 .01
-
An overview of the gut side of the SARS-CoV-2 infection
Intestinal research
2021 .10
-
Bridging therapies to liver transplantation for hepatocellular carcinoma: A bridge to nowhere?
Annals of Hepato-Biliary-Pancreatic Surgery
2018 .02
-
SARS-CoV-2 Infection of Airway Epithelial Cells
Immune Network
2021 .02
-
코로나바이러스 감염병-19와 갑상선 질환
임상이비인후과
2021 .12
-
IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases
Immune Network
2017 .10
-
2019 Novel Coronavirus Disease Outbreak and Molecular Genetic Characteristics of Severe Acute Respiratory Syndrome-Coronavirus-2
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .03
-
Lessons Learned from SARS-CoV and MERS-CoV: Preparation for SARS-CoV-2 induced COVID-19
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .06
-
Thermometry and interpretation of body temperature
Biomedical Engineering Letters (BMEL)
2019 .01
-
알레르기 염증에서의 비만세포 역할과 비만세포 관련 질환
Allergy Asthma & Respiratory Diseases
2017 .01
-
Production and characterization of lentivirus vector-based SARS-CoV-2 pseudoviruses with dual reporters: Evaluation of anti-SARS-CoV-2 viral effect of Korean Red Ginseng
Journal of Ginseng Research
2023 .01
-
Toll-Like Receptor 7 (TLR7) Mediated Transcriptomic Changes on Human Mast Cells
Annals of Dermatology
2021 .10
-
Single Cell Transcriptomic Re-analysis of Immune Cells in Bronchoalveolar Lavage Fluids Reveals the Correlation of B Cell Characteristics and Disease Severity of Patients with SARS-CoV-2 Infection
Immune Network
2021 .02
-
Roles of Interleukin-17 and Th17 Responses in COVID-19
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .09
-
Can Panax ginseng help control cytokine storm in COVID-19?
Journal of Ginseng Research
2022 .05
-
Experimental Animal Models of Coronavirus Infections: Strengths and Limitations
Immune Network
2021 .04
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092511717